Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis

A combination of molecular modeling and structure–activity relationship studies has been used to fine-tune CB2 selectivity in the chromenopyrazole ring, a versatile CB1/CB2 cannabinoid scaffold. Thus, a series of 36 new derivatives covering a wide range of structural diversity has been synthesized,...

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Veröffentlicht in:	Journal of medicinal chemistry 2016-07, Vol.59 (14), p.6753-6771
Hauptverfasser:	Morales, Paula, Gómez-Cañas, María, Navarro, Gemma, Hurst, Dow P, Carrillo-Salinas, Francisco J, Lagartera, Laura, Pazos, Ruth, Goya, Pilar, Reggio, Patricia H, Guaza, Carmen, Franco, Rafael, Fernández-Ruiz, Javier, Jagerovic, Nadine
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug HEK293 Cells Humans Models, Molecular Molecular Structure Multiple Sclerosis - drug therapy Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB2 - agonists Structure-Activity Relationship
Online-Zugang:	Volltext
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