Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1

The basic helix–loop–helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (brain and muscle Arnt-like protein 1) sits at the core of the mammalian circadian transcription/translation feedback loop. Precise control of CLOCK:BMAL1 activity by coactivators and repressors establishes the ∼24-h p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-02, Vol.114 (7), p.1560-1565
Hauptverfasser:	Michael, Alicia K., Fribourgh, Jennifer L., Chelliah, Yogarany, Sandate, Colby R., Hura, Greg L., Schneidman-Duhovny, Dina, Tripathi, Sarvind M., Takahashi, Joseph S., Partch, Carrie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Binding sites Biological Sciences Circadian rhythm circadian rhythms cryptochrome Deoxyribonucleic acid DNA integrative modeling Mammals PAS domains Proteins Scattering Transcription factors
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