Intravoxel incoherent motion diffusion-weighted MR imaging in assessing and characterizing solitary pulmonary lesions

This study aimed to investigate the potential of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in assessing solitary pulmonary lesions (SPLs). Sixty-two patients with pathologically confirmed SPLs, including 51 and 11 cases of malignant and benign lesions, respectively, were asse...

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Veröffentlicht in:Scientific reports 2017-02, Vol.7 (1), p.43257-43257, Article 43257
Hauptverfasser: Wan, Qi, Deng, Ying-Shi, Zhou, Jia-Xuan, Yu, Yu-Dong, Bao, Ying-Ying, Lei, Qiang, Chen, Hou-Jin, Peng, Ya-Hui, Mei, Ying-Jie, Zeng, Qing-Si, Li, Xin-Chun
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container_title Scientific reports
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creator Wan, Qi
Deng, Ying-Shi
Zhou, Jia-Xuan
Yu, Yu-Dong
Bao, Ying-Ying
Lei, Qiang
Chen, Hou-Jin
Peng, Ya-Hui
Mei, Ying-Jie
Zeng, Qing-Si
Li, Xin-Chun
description This study aimed to investigate the potential of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in assessing solitary pulmonary lesions (SPLs). Sixty-two patients with pathologically confirmed SPLs, including 51 and 11 cases of malignant and benign lesions, respectively, were assessed. Diffusion weighted imaging (DWI) with 13 b values was used to derive apparent diffusion coefficient (ADC) and IVIM parameters, including true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f). Our results showed that, there was an excellent inter-observer agreement on the measurements of D and ADC between observers (inter-class correlation coefficient, ICC = 0.902 and 0.884, respectively). Meanwhile, f and D* showed good and substantial reproducibility (ICC = 0.787 and 0.623, respectively). D and ADC of malignant lesions were significantly lower than those of benign lesions (both P ≤ 0.001), while similar values were obtained in both groups for D* and f (both P > 0.05). In receiver operating characteristic (ROC) analysis, D showed the highest area under curve (AUC) for distinguishing malignant from benign lesions, followed by ADC. Accompanying signs of SPLs have specific features on IVIM maps. In conclusion, IVIM provides functional information in characterizing SPLs which is helpful to differential diagnosis. D and ADC have a significantly higher diagnostic value than f and D*.
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Sixty-two patients with pathologically confirmed SPLs, including 51 and 11 cases of malignant and benign lesions, respectively, were assessed. Diffusion weighted imaging (DWI) with 13 b values was used to derive apparent diffusion coefficient (ADC) and IVIM parameters, including true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f). Our results showed that, there was an excellent inter-observer agreement on the measurements of D and ADC between observers (inter-class correlation coefficient, ICC = 0.902 and 0.884, respectively). Meanwhile, f and D* showed good and substantial reproducibility (ICC = 0.787 and 0.623, respectively). D and ADC of malignant lesions were significantly lower than those of benign lesions (both P ≤ 0.001), while similar values were obtained in both groups for D* and f (both P &gt; 0.05). 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D and ADC have a significantly higher diagnostic value than f and D*.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep43257</identifier><identifier>PMID: 28225064</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59 ; 59/36 ; 59/57 ; 692/4028/67/1612 ; 692/4028/67/2321 ; Benign ; Differential diagnosis ; Diffusion coefficient ; Humanities and Social Sciences ; Lungs ; Magnetic resonance imaging ; Mammography ; multidisciplinary ; Perfusion ; Pulmonary lesions ; Science</subject><ispartof>Scientific reports, 2017-02, Vol.7 (1), p.43257-43257, Article 43257</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Feb 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-9450bdebf8670fe81934d1e55191bd92b1df58930eb023b187e577b221d52de73</citedby><cites>FETCH-LOGICAL-c504t-9450bdebf8670fe81934d1e55191bd92b1df58930eb023b187e577b221d52de73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320549/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320549/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28225064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wan, Qi</creatorcontrib><creatorcontrib>Deng, Ying-Shi</creatorcontrib><creatorcontrib>Zhou, Jia-Xuan</creatorcontrib><creatorcontrib>Yu, Yu-Dong</creatorcontrib><creatorcontrib>Bao, Ying-Ying</creatorcontrib><creatorcontrib>Lei, Qiang</creatorcontrib><creatorcontrib>Chen, Hou-Jin</creatorcontrib><creatorcontrib>Peng, Ya-Hui</creatorcontrib><creatorcontrib>Mei, Ying-Jie</creatorcontrib><creatorcontrib>Zeng, Qing-Si</creatorcontrib><creatorcontrib>Li, Xin-Chun</creatorcontrib><title>Intravoxel incoherent motion diffusion-weighted MR imaging in assessing and characterizing solitary pulmonary lesions</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>This study aimed to investigate the potential of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in assessing solitary pulmonary lesions (SPLs). 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Sixty-two patients with pathologically confirmed SPLs, including 51 and 11 cases of malignant and benign lesions, respectively, were assessed. Diffusion weighted imaging (DWI) with 13 b values was used to derive apparent diffusion coefficient (ADC) and IVIM parameters, including true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f). Our results showed that, there was an excellent inter-observer agreement on the measurements of D and ADC between observers (inter-class correlation coefficient, ICC = 0.902 and 0.884, respectively). Meanwhile, f and D* showed good and substantial reproducibility (ICC = 0.787 and 0.623, respectively). D and ADC of malignant lesions were significantly lower than those of benign lesions (both P ≤ 0.001), while similar values were obtained in both groups for D* and f (both P &gt; 0.05). In receiver operating characteristic (ROC) analysis, D showed the highest area under curve (AUC) for distinguishing malignant from benign lesions, followed by ADC. Accompanying signs of SPLs have specific features on IVIM maps. In conclusion, IVIM provides functional information in characterizing SPLs which is helpful to differential diagnosis. D and ADC have a significantly higher diagnostic value than f and D*.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28225064</pmid><doi>10.1038/srep43257</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects 59
59/36
59/57
692/4028/67/1612
692/4028/67/2321
Benign
Differential diagnosis
Diffusion coefficient
Humanities and Social Sciences
Lungs
Magnetic resonance imaging
Mammography
multidisciplinary
Perfusion
Pulmonary lesions
Science
title Intravoxel incoherent motion diffusion-weighted MR imaging in assessing and characterizing solitary pulmonary lesions
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