Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis
Abstract Background Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. Methods...
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| creator | Beauchet, Olivier, MD, PhD Annweiler, Cédric, MD, PhD Callisaya, Michele L., PhD De Cock, Anne-Marie, MD Helbostad, Jorunn L., PhD Kressig, Reto W., MD Srikanth, Velandai, PhD Steinmetz, Jean-Paul, PhD Blumen, Helena M., PhD Verghese, Joe, MD, MBBS Allali, Gilles, MD, PhD |
| description | Abstract Background Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. Methods An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms “Gait” OR “Gait Disorders, Neurologic” OR “Gait Apraxia” OR “Gait Ataxia” AND “Dementia” OR “Frontotemporal Dementia” OR “Dementia, Multi-Infarct” OR “Dementia, Vascular” OR “Alzheimer Disease” OR “Lewy Body Disease” OR “Frontotemporal Dementia With Motor Neuron Disease” (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values. Results Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with P |
| doi_str_mv | 10.1016/j.jamda.2015.12.092 |
| format | Article |
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No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. Methods An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms “Gait” OR “Gait Disorders, Neurologic” OR “Gait Apraxia” OR “Gait Ataxia” AND “Dementia” OR “Frontotemporal Dementia” OR “Dementia, Multi-Infarct” OR “Dementia, Vascular” OR “Alzheimer Disease” OR “Lewy Body Disease” OR “Frontotemporal Dementia With Motor Neuron Disease” (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values. Results Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with P < .001 for any dementia, pooled HR = 1.79 with P < .001 for VaD, HR = 1.89 with P value < .001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with P value = .004). Conclusions This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.</description><identifier>ISSN: 1525-8610</identifier><identifier>EISSN: 1538-9375</identifier><identifier>DOI: 10.1016/j.jamda.2015.12.092</identifier><identifier>PMID: 26852960</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Cognitive science ; dementia ; Dementia - diagnosis ; Epidemiology ; Female ; Gait - physiology ; gait disorders/ataxia ; Humans ; Internal Medicine ; Male ; Medical Education ; motor control ; Predictive Value of Tests ; Psychomotor Performance</subject><ispartof>Journal of the American Medical Directors Association, 2016-06, Vol.17 (6), p.482-490</ispartof><rights>AMDA – The Society for Post-Acute and Long-Term Care Medicine</rights><rights>2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine</rights><rights>Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c564t-f58c454556f56dcd1f48fb7eaf650a520fdece44b64deac2c52d416203c58a2b3</cites><orcidid>0000-0003-2534-4830 ; 0000-0002-7199-8109</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1525861015008518$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26852960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://nantes-universite.hal.science/hal-03295976$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Beauchet, Olivier, MD, PhD</creatorcontrib><creatorcontrib>Annweiler, Cédric, MD, PhD</creatorcontrib><creatorcontrib>Callisaya, Michele L., PhD</creatorcontrib><creatorcontrib>De Cock, Anne-Marie, MD</creatorcontrib><creatorcontrib>Helbostad, Jorunn L., PhD</creatorcontrib><creatorcontrib>Kressig, Reto W., MD</creatorcontrib><creatorcontrib>Srikanth, Velandai, PhD</creatorcontrib><creatorcontrib>Steinmetz, Jean-Paul, PhD</creatorcontrib><creatorcontrib>Blumen, Helena M., PhD</creatorcontrib><creatorcontrib>Verghese, Joe, MD, MBBS</creatorcontrib><creatorcontrib>Allali, Gilles, MD, PhD</creatorcontrib><title>Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis</title><title>Journal of the American Medical Directors Association</title><addtitle>J Am Med Dir Assoc</addtitle><description>Abstract Background Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. Methods An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms “Gait” OR “Gait Disorders, Neurologic” OR “Gait Apraxia” OR “Gait Ataxia” AND “Dementia” OR “Frontotemporal Dementia” OR “Dementia, Multi-Infarct” OR “Dementia, Vascular” OR “Alzheimer Disease” OR “Lewy Body Disease” OR “Frontotemporal Dementia With Motor Neuron Disease” (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values. Results Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with P < .001 for any dementia, pooled HR = 1.79 with P < .001 for VaD, HR = 1.89 with P value < .001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with P value = .004). Conclusions This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cognitive science</subject><subject>dementia</subject><subject>Dementia - diagnosis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gait - physiology</subject><subject>gait disorders/ataxia</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Education</subject><subject>motor control</subject><subject>Predictive Value of Tests</subject><subject>Psychomotor Performance</subject><issn>1525-8610</issn><issn>1538-9375</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhSMEoqXwBEgoS1gk2E6ux0Gi0qj0B2lQR_ysLY99TR2SuLWTkeZteJY-GQ5TKuiGjW3Z55zr689Z9pKSkhLK37Zlq3qjSkYolJSVpGGPskMKlSiaagGP5zWDQnBKDrJnMbaEJGnDn2YHjAtgDSeH2eXa-5CfKzfmawzWh14NGnM1mHwd0Dg9Oj_k3uYfsMdhdOpd_hnj1I0xPwu-z9Xtz084qmI5qG4XXXyePbGqi_jibj7Kvp2dfj25KFaX5x9PlqtCA6_HwoLQNdQA3AI32lBbC7tZoLIciAJGrEGNdb3htUGlmQZmasoZqTQIxTbVUXa8z72eNj0ane4WVCevg-tV2EmvnPz3ZHBX8rvfSqhoA41IAW_2AVcPbBfLlZz3SMWScMG3NGlf3xUL_mbCOMreRY1dpwb0U5R00TCo0sCTtNpLdfAxBrT32ZTIGZts5W9scsYmKZMJW3K9-rube88fTknwfi_A9KZbh0FG7TCRMi6gHqXx7j8Fjh_4decGp1X3A3cYWz-FBDB1ImMyyC_zz5k_DgVCBFBR_QKQ2r-j</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Beauchet, Olivier, MD, PhD</creator><creator>Annweiler, Cédric, MD, PhD</creator><creator>Callisaya, Michele L., PhD</creator><creator>De Cock, Anne-Marie, MD</creator><creator>Helbostad, Jorunn L., PhD</creator><creator>Kressig, Reto W., MD</creator><creator>Srikanth, Velandai, PhD</creator><creator>Steinmetz, Jean-Paul, PhD</creator><creator>Blumen, Helena M., PhD</creator><creator>Verghese, Joe, MD, MBBS</creator><creator>Allali, Gilles, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2534-4830</orcidid><orcidid>https://orcid.org/0000-0002-7199-8109</orcidid></search><sort><creationdate>20160601</creationdate><title>Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis</title><author>Beauchet, Olivier, MD, PhD ; Annweiler, Cédric, MD, PhD ; Callisaya, Michele L., PhD ; De Cock, Anne-Marie, MD ; Helbostad, Jorunn L., PhD ; Kressig, Reto W., MD ; Srikanth, Velandai, PhD ; Steinmetz, Jean-Paul, PhD ; Blumen, Helena M., PhD ; Verghese, Joe, MD, MBBS ; Allali, Gilles, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-f58c454556f56dcd1f48fb7eaf650a520fdece44b64deac2c52d416203c58a2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cognitive science</topic><topic>dementia</topic><topic>Dementia - diagnosis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gait - physiology</topic><topic>gait disorders/ataxia</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical Education</topic><topic>motor control</topic><topic>Predictive Value of Tests</topic><topic>Psychomotor Performance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beauchet, Olivier, MD, PhD</creatorcontrib><creatorcontrib>Annweiler, Cédric, MD, PhD</creatorcontrib><creatorcontrib>Callisaya, Michele L., PhD</creatorcontrib><creatorcontrib>De Cock, Anne-Marie, MD</creatorcontrib><creatorcontrib>Helbostad, Jorunn L., PhD</creatorcontrib><creatorcontrib>Kressig, Reto W., MD</creatorcontrib><creatorcontrib>Srikanth, Velandai, PhD</creatorcontrib><creatorcontrib>Steinmetz, Jean-Paul, PhD</creatorcontrib><creatorcontrib>Blumen, Helena M., PhD</creatorcontrib><creatorcontrib>Verghese, Joe, MD, MBBS</creatorcontrib><creatorcontrib>Allali, Gilles, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Medical Directors Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beauchet, Olivier, MD, PhD</au><au>Annweiler, Cédric, MD, PhD</au><au>Callisaya, Michele L., PhD</au><au>De Cock, Anne-Marie, MD</au><au>Helbostad, Jorunn L., PhD</au><au>Kressig, Reto W., MD</au><au>Srikanth, Velandai, PhD</au><au>Steinmetz, Jean-Paul, PhD</au><au>Blumen, Helena M., PhD</au><au>Verghese, Joe, MD, MBBS</au><au>Allali, Gilles, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis</atitle><jtitle>Journal of the American Medical Directors Association</jtitle><addtitle>J Am Med Dir Assoc</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>17</volume><issue>6</issue><spage>482</spage><epage>490</epage><pages>482-490</pages><issn>1525-8610</issn><eissn>1538-9375</eissn><abstract>Abstract Background Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. Methods An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms “Gait” OR “Gait Disorders, Neurologic” OR “Gait Apraxia” OR “Gait Ataxia” AND “Dementia” OR “Frontotemporal Dementia” OR “Dementia, Multi-Infarct” OR “Dementia, Vascular” OR “Alzheimer Disease” OR “Lewy Body Disease” OR “Frontotemporal Dementia With Motor Neuron Disease” (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values. Results Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with P < .001 for any dementia, pooled HR = 1.79 with P < .001 for VaD, HR = 1.89 with P value < .001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with P value = .004). Conclusions This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26852960</pmid><doi>10.1016/j.jamda.2015.12.092</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2534-4830</orcidid><orcidid>https://orcid.org/0000-0002-7199-8109</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Aged, 80 and over Cognitive science dementia Dementia - diagnosis Epidemiology Female Gait - physiology gait disorders/ataxia Humans Internal Medicine Male Medical Education motor control Predictive Value of Tests Psychomotor Performance |
| title | Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis |
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