Comparison of the pro-postoperative analgesia of intraoperative dexmedetomidine with and without loading dose following general anesthesia: A prospective, randomized, controlled clinical trial
Intraoperative dexemdetomidine (DEX) with or without loading dose is well-established to improve postoperative pain control in patient-controlled analgesia (PCA). This study was designed to compare the pro-analgesia effect between the 2 in patients received general anesthesia.Seventy patients shcedu...
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| Veröffentlicht in: | Medicine (Baltimore) 2017-02, Vol.96 (7), p.e6106-e6106 |
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| creator | Fan, Wei Yang, Haikou Sun, Yong Zhang, Jun Li, Guangming Zheng, Ying Liu, Yi |
| description | Intraoperative dexemdetomidine (DEX) with or without loading dose is well-established to improve postoperative pain control in patient-controlled analgesia (PCA). This study was designed to compare the pro-analgesia effect between the 2 in patients received general anesthesia.Seventy patients shceduced abdominal surgery under general anesthesia were randomly assigned into 3 groups which were maintained using propofol/remifentanil/Ringer solution (PRR), propofol/remifentanil/dexmedetomidine with (PRDw) or without (PRDo) a loading dose of dexmedetomidine before induction.PRDw/o patients displayed a greater Romsay sedation score measured immediately after surgery. When compared with PRR patients, those from the PRDw/o group had an increased time to first request of postoperative morphine and decreased 24 hours total morphine consumption. No significant difference was observed between patients from the PRDw and PRDo groups with respect to these parameters.The present study suggests that the administration of a DEX loading dose does not affect the pro-analgesic effect of intraoperative use of DEX on morphine-based PCA. |
| doi_str_mv | 10.1097/MD.0000000000006106 |
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This study was designed to compare the pro-analgesia effect between the 2 in patients received general anesthesia.Seventy patients shceduced abdominal surgery under general anesthesia were randomly assigned into 3 groups which were maintained using propofol/remifentanil/Ringer solution (PRR), propofol/remifentanil/dexmedetomidine with (PRDw) or without (PRDo) a loading dose of dexmedetomidine before induction.PRDw/o patients displayed a greater Romsay sedation score measured immediately after surgery. When compared with PRR patients, those from the PRDw/o group had an increased time to first request of postoperative morphine and decreased 24 hours total morphine consumption. No significant difference was observed between patients from the PRDw and PRDo groups with respect to these parameters.The present study suggests that the administration of a DEX loading dose does not affect the pro-analgesic effect of intraoperative use of DEX on morphine-based PCA.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000006106</identifier><identifier>PMID: 28207529</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Aged ; Analgesics, Non-Narcotic - administration & dosage ; Analgesics, Non-Narcotic - adverse effects ; Analgesics, Non-Narcotic - therapeutic use ; Anesthesia, General - methods ; Dexmedetomidine - administration & dosage ; Dexmedetomidine - adverse effects ; Dexmedetomidine - therapeutic use ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Heart Rate ; Humans ; Intraoperative Period ; Male ; Middle Aged ; Observational Study ; Pain, Postoperative - drug therapy ; Postoperative Period ; Propofol - administration & dosage ; Prospective Studies</subject><ispartof>Medicine (Baltimore), 2017-02, Vol.96 (7), p.e6106-e6106</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3553-90be91a0d627eb5d10cd992a03622d5e04136577fa026eb8b8947841b3dff26e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319518/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319518/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28207529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Wei</creatorcontrib><creatorcontrib>Yang, Haikou</creatorcontrib><creatorcontrib>Sun, Yong</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Li, Guangming</creatorcontrib><creatorcontrib>Zheng, Ying</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><title>Comparison of the pro-postoperative analgesia of intraoperative dexmedetomidine with and without loading dose following general anesthesia: A prospective, randomized, controlled clinical trial</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Intraoperative dexemdetomidine (DEX) with or without loading dose is well-established to improve postoperative pain control in patient-controlled analgesia (PCA). This study was designed to compare the pro-analgesia effect between the 2 in patients received general anesthesia.Seventy patients shceduced abdominal surgery under general anesthesia were randomly assigned into 3 groups which were maintained using propofol/remifentanil/Ringer solution (PRR), propofol/remifentanil/dexmedetomidine with (PRDw) or without (PRDo) a loading dose of dexmedetomidine before induction.PRDw/o patients displayed a greater Romsay sedation score measured immediately after surgery. When compared with PRR patients, those from the PRDw/o group had an increased time to first request of postoperative morphine and decreased 24 hours total morphine consumption. No significant difference was observed between patients from the PRDw and PRDo groups with respect to these parameters.The present study suggests that the administration of a DEX loading dose does not affect the pro-analgesic effect of intraoperative use of DEX on morphine-based PCA.</description><subject>Adult</subject><subject>Aged</subject><subject>Analgesics, Non-Narcotic - administration & dosage</subject><subject>Analgesics, Non-Narcotic - adverse effects</subject><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Anesthesia, General - methods</subject><subject>Dexmedetomidine - administration & dosage</subject><subject>Dexmedetomidine - adverse effects</subject><subject>Dexmedetomidine - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Intraoperative Period</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Postoperative Period</subject><subject>Propofol - administration & dosage</subject><subject>Prospective Studies</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtu1DAQhi0EokvhCZCQH6ApPsRxzAVSteUkteIGriMnnuwavHFke7vA0_FoTLpQCpYs2zP__43GQ8hzzs45M_rl9eU5u7cazpoHZMWVbCplmvohWTEmVKWNrk_Ik5y_MMalFvVjciJawbQSZkV-ruNutsnnONE40rIFOqdYzTGXOEOyxd8AtZMNG8jeLhI_lWT_5hx824GDEnfe-QnowZctGtztJe4LDdFiYkNdzEDHGEI8LM8NTIgIKIWMVRH-il4stfMMw0I-owkxiP0B7owOEcuiGRwdgp_8gNaSvA1PyaPRhgzPfp-n5PPbN5_W76urj-8-rC-uqkEqJSvDejDcMtcIDb1ynA3OGGGZbIRwCljNZaO0Hi0TDfRt35patzXvpRtHjMhT8vrInfc9NjzA8g2hm5Pf2fS9i9Z3_2Ymv-028aZTkhvFWwTII2DAHnOC8c7LWbcMtLu-7P4fKLpe3C975_kzQRTUR8EhhgIpfw37A6RuCzaU7S1PaSMqwbhmAneFESnlLwLEsng</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Fan, Wei</creator><creator>Yang, Haikou</creator><creator>Sun, Yong</creator><creator>Zhang, Jun</creator><creator>Li, Guangming</creator><creator>Zheng, Ying</creator><creator>Liu, Yi</creator><general>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20170201</creationdate><title>Comparison of the pro-postoperative analgesia of intraoperative dexmedetomidine with and without loading dose following general anesthesia: A prospective, randomized, controlled clinical trial</title><author>Fan, Wei ; Yang, Haikou ; Sun, Yong ; Zhang, Jun ; Li, Guangming ; Zheng, Ying ; Liu, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3553-90be91a0d627eb5d10cd992a03622d5e04136577fa026eb8b8947841b3dff26e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analgesics, Non-Narcotic - administration & dosage</topic><topic>Analgesics, Non-Narcotic - adverse effects</topic><topic>Analgesics, Non-Narcotic - therapeutic use</topic><topic>Anesthesia, General - methods</topic><topic>Dexmedetomidine - administration & dosage</topic><topic>Dexmedetomidine - adverse effects</topic><topic>Dexmedetomidine - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Intraoperative Period</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Postoperative Period</topic><topic>Propofol - administration & dosage</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Wei</creatorcontrib><creatorcontrib>Yang, Haikou</creatorcontrib><creatorcontrib>Sun, Yong</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Li, Guangming</creatorcontrib><creatorcontrib>Zheng, Ying</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Wei</au><au>Yang, Haikou</au><au>Sun, Yong</au><au>Zhang, Jun</au><au>Li, Guangming</au><au>Zheng, Ying</au><au>Liu, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the pro-postoperative analgesia of intraoperative dexmedetomidine with and without loading dose following general anesthesia: A prospective, randomized, controlled clinical trial</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>96</volume><issue>7</issue><spage>e6106</spage><epage>e6106</epage><pages>e6106-e6106</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Intraoperative dexemdetomidine (DEX) with or without loading dose is well-established to improve postoperative pain control in patient-controlled analgesia (PCA). This study was designed to compare the pro-analgesia effect between the 2 in patients received general anesthesia.Seventy patients shceduced abdominal surgery under general anesthesia were randomly assigned into 3 groups which were maintained using propofol/remifentanil/Ringer solution (PRR), propofol/remifentanil/dexmedetomidine with (PRDw) or without (PRDo) a loading dose of dexmedetomidine before induction.PRDw/o patients displayed a greater Romsay sedation score measured immediately after surgery. When compared with PRR patients, those from the PRDw/o group had an increased time to first request of postoperative morphine and decreased 24 hours total morphine consumption. No significant difference was observed between patients from the PRDw and PRDo groups with respect to these parameters.The present study suggests that the administration of a DEX loading dose does not affect the pro-analgesic effect of intraoperative use of DEX on morphine-based PCA.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>28207529</pmid><doi>10.1097/MD.0000000000006106</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - adverse effects Analgesics, Non-Narcotic - therapeutic use Anesthesia, General - methods Dexmedetomidine - administration & dosage Dexmedetomidine - adverse effects Dexmedetomidine - therapeutic use Dose-Response Relationship, Drug Double-Blind Method Female Heart Rate Humans Intraoperative Period Male Middle Aged Observational Study Pain, Postoperative - drug therapy Postoperative Period Propofol - administration & dosage Prospective Studies |
| title | Comparison of the pro-postoperative analgesia of intraoperative dexmedetomidine with and without loading dose following general anesthesia: A prospective, randomized, controlled clinical trial |
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