Stellera chamaejasme and its constituents induce cutaneous wound healing and anti-inflammatory activities
Stellera chamaejasme L. (Thymelaeaceae) is a perennial herb that is widely used in traditional Chinese medicine to treat tumours, tuberculosis and psoriasis. S. chamaejasme extract (SCE) possesses anti-inflammatory, analgesic and wound healing activities; however, the effect of S. chamaejasme and it...
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| description | Stellera chamaejasme
L. (Thymelaeaceae) is a perennial herb that is widely used in traditional Chinese medicine to treat tumours, tuberculosis and psoriasis.
S. chamaejasme
extract (SCE) possesses anti-inflammatory, analgesic and wound healing activities; however, the effect of
S. chamaejasme
and its active compounds on cutaneous wound healing has not been investigated. We assessed full-thickness wounds of Sprague-Dawley (SD) rats and topically applied SCE for 2 weeks.
In vitro
studies were performed using HaCaT keratinocytes, Hs68 dermal fibroblasts and RAW 264.7 macrophages to determine cell viability (MTT assay), cell migration, collagen expression, nitric oxide (NO) production, prostaglandin E
2
(PGE
2
) production, inflammatory cytokine expression and β-catenin activation.
In vivo
, wound size was reduced and epithelisation was improved in SCE-treated SD rats.
In vitro
, SCE and its active compounds induced keratinocyte migration by regulating the β-catenin, extracellular signal-regulated kinase and Akt signalling pathways. Furthermore, SCE and its active compounds increased mRNA expression of type I and III collagen in Hs68 fibroblasts. SCE and chamechromone inhibited NO and PGE
2
release and mRNA expression of inflammatory mediators in RAW 264.7 macrophages. SCE enhances the motility of HaCaT keratinocytes and improves cutaneous wound healing in SD rats. |
| doi_str_mv | 10.1038/srep42490 |
| format | Article |
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L. (Thymelaeaceae) is a perennial herb that is widely used in traditional Chinese medicine to treat tumours, tuberculosis and psoriasis.
S. chamaejasme
extract (SCE) possesses anti-inflammatory, analgesic and wound healing activities; however, the effect of
S. chamaejasme
and its active compounds on cutaneous wound healing has not been investigated. We assessed full-thickness wounds of Sprague-Dawley (SD) rats and topically applied SCE for 2 weeks.
In vitro
studies were performed using HaCaT keratinocytes, Hs68 dermal fibroblasts and RAW 264.7 macrophages to determine cell viability (MTT assay), cell migration, collagen expression, nitric oxide (NO) production, prostaglandin E
2
(PGE
2
) production, inflammatory cytokine expression and β-catenin activation.
In vivo
, wound size was reduced and epithelisation was improved in SCE-treated SD rats.
In vitro
, SCE and its active compounds induced keratinocyte migration by regulating the β-catenin, extracellular signal-regulated kinase and Akt signalling pathways. Furthermore, SCE and its active compounds increased mRNA expression of type I and III collagen in Hs68 fibroblasts. SCE and chamechromone inhibited NO and PGE
2
release and mRNA expression of inflammatory mediators in RAW 264.7 macrophages. SCE enhances the motility of HaCaT keratinocytes and improves cutaneous wound healing in SD rats.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep42490</identifier><identifier>PMID: 28220834</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/109 ; 13/21 ; 13/51 ; 13/95 ; 38/77 ; 631/154/309/436/108 ; 692/308/153 ; AKT protein ; Analgesics ; Animals ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; Cell adhesion & migration ; Cell Line ; Chinese medicine ; Chromatography, Liquid ; Collagen ; Collagen (type I) ; Collagen - genetics ; Collagen - metabolism ; Extracellular signal-regulated kinase ; Extracellular Signal-Regulated MAP Kinases - metabolism ; Fibroblasts ; Gene expression ; Herbal medicine ; Humanities and Social Sciences ; Humans ; Inflammation ; Inflammation Mediators - metabolism ; Keratinocytes ; Leukocyte migration ; Macrophages ; Macrophages - drug effects ; Macrophages - metabolism ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Mice ; Molecular Structure ; multidisciplinary ; Nitric oxide ; Oncogene Protein v-akt - metabolism ; Phytochemicals - chemistry ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Prostaglandin E2 ; Psoriasis ; Rats ; Rodents ; Science ; Signal transduction ; Skin ; Skin - metabolism ; Skin - pathology ; Skin diseases ; Thymelaeaceae - chemistry ; Traditional Chinese medicine ; Tuberculosis ; Tumors ; Wound healing ; Wound Healing - drug effects ; β-Catenin</subject><ispartof>Scientific reports, 2017-02, Vol.7 (1), p.42490-42490, Article 42490</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Feb 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-e2db5a9823a46c8c6c28867320f68931a86d29ba5acf9e02a6e7b70748e1ac233</citedby><cites>FETCH-LOGICAL-c438t-e2db5a9823a46c8c6c28867320f68931a86d29ba5acf9e02a6e7b70748e1ac233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318992/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318992/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28220834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Myungsuk</creatorcontrib><creatorcontrib>Lee, Hee Ju</creatorcontrib><creatorcontrib>Randy, Ahmad</creatorcontrib><creatorcontrib>Yun, Ji Ho</creatorcontrib><creatorcontrib>Oh, Sang-Rok</creatorcontrib><creatorcontrib>Nho, Chu Won</creatorcontrib><title>Stellera chamaejasme and its constituents induce cutaneous wound healing and anti-inflammatory activities</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Stellera chamaejasme
L. (Thymelaeaceae) is a perennial herb that is widely used in traditional Chinese medicine to treat tumours, tuberculosis and psoriasis.
S. chamaejasme
extract (SCE) possesses anti-inflammatory, analgesic and wound healing activities; however, the effect of
S. chamaejasme
and its active compounds on cutaneous wound healing has not been investigated. We assessed full-thickness wounds of Sprague-Dawley (SD) rats and topically applied SCE for 2 weeks.
In vitro
studies were performed using HaCaT keratinocytes, Hs68 dermal fibroblasts and RAW 264.7 macrophages to determine cell viability (MTT assay), cell migration, collagen expression, nitric oxide (NO) production, prostaglandin E
2
(PGE
2
) production, inflammatory cytokine expression and β-catenin activation.
In vivo
, wound size was reduced and epithelisation was improved in SCE-treated SD rats.
In vitro
, SCE and its active compounds induced keratinocyte migration by regulating the β-catenin, extracellular signal-regulated kinase and Akt signalling pathways. Furthermore, SCE and its active compounds increased mRNA expression of type I and III collagen in Hs68 fibroblasts. SCE and chamechromone inhibited NO and PGE
2
release and mRNA expression of inflammatory mediators in RAW 264.7 macrophages. SCE enhances the motility of HaCaT keratinocytes and improves cutaneous wound healing in SD rats.</description><subject>13/1</subject><subject>13/109</subject><subject>13/21</subject><subject>13/51</subject><subject>13/95</subject><subject>38/77</subject><subject>631/154/309/436/108</subject><subject>692/308/153</subject><subject>AKT protein</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Cell adhesion & migration</subject><subject>Cell Line</subject><subject>Chinese medicine</subject><subject>Chromatography, Liquid</subject><subject>Collagen</subject><subject>Collagen (type I)</subject><subject>Collagen - genetics</subject><subject>Collagen - metabolism</subject><subject>Extracellular signal-regulated kinase</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>Fibroblasts</subject><subject>Gene expression</subject><subject>Herbal medicine</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Keratinocytes</subject><subject>Leukocyte migration</subject><subject>Macrophages</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mass Spectrometry</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>multidisciplinary</subject><subject>Nitric oxide</subject><subject>Oncogene Protein v-akt - metabolism</subject><subject>Phytochemicals - chemistry</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Prostaglandin E2</subject><subject>Psoriasis</subject><subject>Rats</subject><subject>Rodents</subject><subject>Science</subject><subject>Signal transduction</subject><subject>Skin</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin diseases</subject><subject>Thymelaeaceae - chemistry</subject><subject>Traditional Chinese medicine</subject><subject>Tuberculosis</subject><subject>Tumors</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>β-Catenin</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkV9LHDEUxUNRqqgP_QJloC9WGJt_M5O8FIq0Kgh9aPsc7mbu7GaZSdYkY_HbN3btsta8JOH-cnLuPYS8Y_SSUaE-pYgbyaWmb8gxp7KpueD8YO98RM5SWtOyGq4l02_JEVecUyXkMXE_Mo4jRqjsCibANaQJK_B95XKqbPApuzyjLxfn-9liZecMHsOcqt9hLtwKYXR--fcN-Oxq54cRpglyiI8V2OweXHaYTsnhAGPCs-f9hPz69vXn1U199_369urLXW2lULlG3i8a0IoLkK1VtrVcqbYTnA6t0oKBanuuF9CAHTRSDi12i452UiEDy4U4IZ-3upt5MWFvi_cIo9lEN0F8NAGceVnxbmWW4cE0gimteRE4fxaI4X7GlM3kki1T2rZtmOpoK6Vsn9AP_6HrMEdf2jNMU9aVIWtWqI9bysaQSlzDzgyj5ilDs8uwsO_33e_If4kV4GILpFLyS4x7X75S-wNQc6gD</recordid><startdate>20170221</startdate><enddate>20170221</enddate><creator>Kim, Myungsuk</creator><creator>Lee, Hee Ju</creator><creator>Randy, Ahmad</creator><creator>Yun, Ji Ho</creator><creator>Oh, Sang-Rok</creator><creator>Nho, Chu Won</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170221</creationdate><title>Stellera chamaejasme and its constituents induce cutaneous wound healing and anti-inflammatory activities</title><author>Kim, Myungsuk ; Lee, Hee Ju ; Randy, Ahmad ; Yun, Ji Ho ; Oh, Sang-Rok ; Nho, Chu Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-e2db5a9823a46c8c6c28867320f68931a86d29ba5acf9e02a6e7b70748e1ac233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>13/1</topic><topic>13/109</topic><topic>13/21</topic><topic>13/51</topic><topic>13/95</topic><topic>38/77</topic><topic>631/154/309/436/108</topic><topic>692/308/153</topic><topic>AKT protein</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Cell adhesion & migration</topic><topic>Cell Line</topic><topic>Chinese medicine</topic><topic>Chromatography, Liquid</topic><topic>Collagen</topic><topic>Collagen (type I)</topic><topic>Collagen - genetics</topic><topic>Collagen - metabolism</topic><topic>Extracellular signal-regulated kinase</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Fibroblasts</topic><topic>Gene expression</topic><topic>Herbal medicine</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Keratinocytes</topic><topic>Leukocyte migration</topic><topic>Macrophages</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mass Spectrometry</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>multidisciplinary</topic><topic>Nitric oxide</topic><topic>Oncogene Protein v-akt - metabolism</topic><topic>Phytochemicals - chemistry</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Prostaglandin E2</topic><topic>Psoriasis</topic><topic>Rats</topic><topic>Rodents</topic><topic>Science</topic><topic>Signal transduction</topic><topic>Skin</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>Skin diseases</topic><topic>Thymelaeaceae - chemistry</topic><topic>Traditional Chinese medicine</topic><topic>Tuberculosis</topic><topic>Tumors</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>β-Catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Myungsuk</creatorcontrib><creatorcontrib>Lee, Hee Ju</creatorcontrib><creatorcontrib>Randy, Ahmad</creatorcontrib><creatorcontrib>Yun, Ji Ho</creatorcontrib><creatorcontrib>Oh, Sang-Rok</creatorcontrib><creatorcontrib>Nho, Chu Won</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Myungsuk</au><au>Lee, Hee Ju</au><au>Randy, Ahmad</au><au>Yun, Ji Ho</au><au>Oh, Sang-Rok</au><au>Nho, Chu Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stellera chamaejasme and its constituents induce cutaneous wound healing and anti-inflammatory activities</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-02-21</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>42490</spage><epage>42490</epage><pages>42490-42490</pages><artnum>42490</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Stellera chamaejasme
L. (Thymelaeaceae) is a perennial herb that is widely used in traditional Chinese medicine to treat tumours, tuberculosis and psoriasis.
S. chamaejasme
extract (SCE) possesses anti-inflammatory, analgesic and wound healing activities; however, the effect of
S. chamaejasme
and its active compounds on cutaneous wound healing has not been investigated. We assessed full-thickness wounds of Sprague-Dawley (SD) rats and topically applied SCE for 2 weeks.
In vitro
studies were performed using HaCaT keratinocytes, Hs68 dermal fibroblasts and RAW 264.7 macrophages to determine cell viability (MTT assay), cell migration, collagen expression, nitric oxide (NO) production, prostaglandin E
2
(PGE
2
) production, inflammatory cytokine expression and β-catenin activation.
In vivo
, wound size was reduced and epithelisation was improved in SCE-treated SD rats.
In vitro
, SCE and its active compounds induced keratinocyte migration by regulating the β-catenin, extracellular signal-regulated kinase and Akt signalling pathways. Furthermore, SCE and its active compounds increased mRNA expression of type I and III collagen in Hs68 fibroblasts. SCE and chamechromone inhibited NO and PGE
2
release and mRNA expression of inflammatory mediators in RAW 264.7 macrophages. SCE enhances the motility of HaCaT keratinocytes and improves cutaneous wound healing in SD rats.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28220834</pmid><doi>10.1038/srep42490</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/1 13/109 13/21 13/51 13/95 38/77 631/154/309/436/108 692/308/153 AKT protein Analgesics Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Cell adhesion & migration Cell Line Chinese medicine Chromatography, Liquid Collagen Collagen (type I) Collagen - genetics Collagen - metabolism Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblasts Gene expression Herbal medicine Humanities and Social Sciences Humans Inflammation Inflammation Mediators - metabolism Keratinocytes Leukocyte migration Macrophages Macrophages - drug effects Macrophages - metabolism Magnetic Resonance Spectroscopy Mass Spectrometry Mice Molecular Structure multidisciplinary Nitric oxide Oncogene Protein v-akt - metabolism Phytochemicals - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Prostaglandin E2 Psoriasis Rats Rodents Science Signal transduction Skin Skin - metabolism Skin - pathology Skin diseases Thymelaeaceae - chemistry Traditional Chinese medicine Tuberculosis Tumors Wound healing Wound Healing - drug effects β-Catenin |
| title | Stellera chamaejasme and its constituents induce cutaneous wound healing and anti-inflammatory activities |
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