Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes

Aging is one of the most prominent risk factors for the pathological progression of osteoarthritis (OA). One feature of age-related changes in OA is advanced glycation end products (AGEs) accumulation in articular cartilage. Autophagy plays a cellular housekeeping role by removing dysfunctional cell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BioMed research international 2017-01, Vol.2017 (2017), p.1-9
Hauptverfasser:	Cheng, Xigao, Yin, Changchang, Deng, Zhongbo, Xu, Libiao, Wu, Tianlong, Li, Jian, Ao, Peng, Huang, Wenzhou, Chen, Wenjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Age Aging Animals Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biomedical research Care and treatment Cells, Cultured Chondrocytes - cytology Chondrocytes - enzymology Collagen Development and progression Extracellular matrix Gene expression Gene Expression Regulation, Enzymologic - drug effects Glycation End Products, Advanced - pharmacology Health aspects Homeostasis Laboratories Matrix Metalloproteinase 13 - biosynthesis Matrix Metalloproteinase 3 - biosynthesis Osteoarthritis Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!