Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

Cerebral dopamine neurotrophic factor (CDNF) protects the nigrostriatal dopaminergic (DA) neurons in rodent models of Parkinson's disease and restores DA circuitry when delivered after these neurons have begun to degenerate. These DA neurons have been suggested to transport striatal CDNF retrog...

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Veröffentlicht in:	eNeuro 2017-01, Vol.4 (1), p.ENEURO.0128-16.2017
Hauptverfasser:	Mätlik, Kert, Vihinen, Helena, Bienemann, Ali, Palgi, Jaan, Voutilainen, Merja H, Booms, Sigrid, Lindahl, Maria, Jokitalo, Eija, Saarma, Mart, Huttunen, Henri J, Airavaara, Mikko, Arumäe, Urmas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Agents - pharmacology Animals Corpus Striatum - drug effects Corpus Striatum - metabolism Dopaminergic Neurons - metabolism Dopaminergic Neurons - ultrastructure Endocytosis - drug effects Endocytosis - physiology Humans Male Mice Microscopy, Immunoelectron Nerve Growth Factors - administration & dosage Nerve Growth Factors - metabolism Nerve Growth Factors - ultrastructure Neural Pathways - drug effects Neural Pathways - physiology New Research Oxidopamine - pharmacology Phosphopyruvate Hydratase - metabolism Protein Transport - drug effects Protein Transport - genetics Rats Rats, Transgenic Rats, Wistar Substantia Nigra - drug effects Substantia Nigra - metabolism Time Factors Tyrosine 3-Monooxygenase - metabolism
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