The ICl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP2

Inwardly rectifying K + (Kir) channels are important contributors to the resting membrane potential and regulate cellular excitability. The activity of Kir channels depends critically on the phospholipid PIP 2 . Several modulators of the activity of Kir channels alter the apparent affinity of the ch...

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Veröffentlicht in:	Pflügers Archiv 2016-05, Vol.468 (5), p.817-824
Hauptverfasser:	Deng, Wu, Mahajan, Rahul, Baumgarten, Clive M., Logothetis, Diomedes E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Size - drug effects Cells, Cultured Chloride Channels - antagonists & inhibitors Chloride Channels - metabolism Cyclopentanes - pharmacology Human Physiology Indans - pharmacology Ion Channels Molecular Medicine Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - physiology Neurosciences Phosphatidylinositol 4,5-Diphosphate - metabolism Potassium Channels, Inwardly Rectifying - antagonists & inhibitors Potassium Channels, Inwardly Rectifying - drug effects Rabbits Receptors Receptors and Transporters Xenopus
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