Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina

Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss and blindness. We have previously shown in the rd10 mouse model of RP, that rd10 microglia drive degeneration of viable neurons. Norgestrel, a progesterone analogue, primes viable neurons against potent...

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Veröffentlicht in:	Scientific reports 2017-02, Vol.7 (1), p.43067-43067, Article 43067
Hauptverfasser:	Roche, Sarah L., Wyse-Jackson, Alice C., Ruiz-Lopez, Ana M., Byrne, Ashleigh M., Cotter, Thomas G.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/21 13/51 631/378/2596/1953 64/60 692/699/3161/3175 96/63 Animals Blindness Cell culture Cells, Cultured Chemokine CX3CL1 - metabolism CX3C Chemokine Receptor 1 - metabolism CX3CR1 protein Cytokines Degeneration Disease Models, Animal Explants Female Fractalkine Humanities and Social Sciences Inflammation Male Mice Microglia multidisciplinary Neuroprotection Norgestrel - pharmacology Photoreceptor Cells - drug effects Photoreceptor Cells - metabolism Photoreceptor Cells - physiology Photoreceptors Progesterone Progesterone - pharmacology Retina Retina - drug effects Retina - metabolism Retina - physiology Retinitis Retinitis pigmentosa Science Signal Transduction Survival
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