Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017

Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network (SPSN) assessed interim 2016/17 influenza vaccine effectiveness (VE) against dominant influenza A(H3N2) viruses considered antigenically matched to the clade 3C.2a vaccine strain. Sequence analysis revealed substan...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2017-02, Vol.22 (6), p.1
Hauptverfasser:	Skowronski, Danuta M, Chambers, Catharine, Sabaiduc, Suzana, Dickinson, James A, Winter, Anne-Luise, De Serres, Gaston, Drews, Steven J, Jassem, Agatha, Gubbay, Jonathan B, Charest, Hugues, Balshaw, Robert, Bastien, Nathalie, Li, Yan, Krajden, Mel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Canada - epidemiology Case-Control Studies Child Child, Preschool Disease transmission Female Hemagglutination Inhibition Tests Humans Infant Influenza Influenza A Virus, H3N2 Subtype - genetics Influenza A Virus, H3N2 Subtype - immunology Influenza A Virus, H3N2 Subtype - isolation & purification Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - diagnosis Influenza, Human - epidemiology Influenza, Human - prevention & control Influenza, Human - virology Middle Aged Outcome Assessment, Health Care Rapid Communication Reverse Transcriptase Polymerase Chain Reaction Seasons Sentinel Surveillance Sequence Analysis, DNA Vaccination - statistics & numerical data Vaccine Potency Vaccines Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network (SPSN) assessed interim 2016/17 influenza vaccine effectiveness (VE) against dominant influenza A(H3N2) viruses considered antigenically matched to the clade 3C.2a vaccine strain. Sequence analysis revealed substantial heterogeneity in emerging 3C.2a1 variants by province and over time. Adjusted VE was 42% (95% confidence interval: 18-59%) overall, with variation by province. Interim virological and VE findings reported here warrant further investigation to inform potential vaccine reformulation.
ISSN:	1560-7917 1025-496X 1560-7917
DOI:	10.2807/1560-7917.ES.2017.22.6.30460