miR-216 and miR-217 expression is reduced in transgenic mouse models of pancreatic adenocarcinoma, knockout of miR-216/miR-217 host gene is embryonic lethal

Mice harboring a G12D activating Kras mutation are among the most heavily studied models in the field of pancreatic adenocarcinoma (PDAC) research. miRNAs are differentially expressed in PDAC from patients and mouse models of PDAC. To better understand the relationship that Kras activation has on mi...

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Veröffentlicht in:	Functional & integrative genomics 2017-05, Vol.17 (2-3), p.203-212
Hauptverfasser:	Azevedo-Pouly, Ana Clara P., Sutaria, Dhruvitkumar S., Jiang, Jinmai, Elgamal, Ola A., Amari, Foued, Allard, David, Grippo, Paul J., Coppola, Vincenzo, Schmittgen, Thomas D.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma Adenocarcinoma - genetics Animal Genetics and Genomics animal models Animals Biochemistry Bioinformatics Biomedical and Life Sciences Cell Biology Gene expression gene expression regulation genes Genes, Lethal germ cells heterozygosity humans Life Sciences Mice Mice, Transgenic Microbial Genetics and Genomics microRNA MicroRNAs MicroRNAs - genetics mortality mutation Original Article pancreas Pancreatic cancer Pancreatic Neoplasms - genetics patients phenotype Plant Genetics and Genomics quantitative polymerase chain reaction Rodents Transgenic animals
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