Emerging roles and context of circular RNAs
Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have recently emerged as regulators of gene expression. They have been shown to suppress microRNAs, thereby increasing the translation and stability of the targets of such microRNAs. In this review, we discuss the emerg...
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| Veröffentlicht in: | Wiley interdisciplinary reviews. RNA 2017-03, Vol.8 (2), p.np-n/a |
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| creator | Panda, Amaresh C. Grammatikakis, Ioannis Munk, Rachel Gorospe, Myriam Abdelmohsen, Kotb |
| description | Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have recently emerged as regulators of gene expression. They have been shown to suppress microRNAs, thereby increasing the translation and stability of the targets of such microRNAs. In this review, we discuss the emerging functions of circRNAs, including RNA transcription, splicing, turnover, and translation. We also discuss other possible facets of circRNAs that can influence their function depending on the cell context, such as circRNA abundance, subcellular localization, interacting partners (RNA, DNA, and proteins), dynamic changes in interactions following stimulation, and potential circRNA translation. The ensuing changes in gene expression patterns elicited by circRNAs are proposed to drive key cellular processes, such as cell proliferation, differentiation, and survival, that govern health and disease. WIREs RNA 2017, 8:e1386. doi: 10.1002/wrna.1386
This article is categorized under:
RNA-Based Catalysis > RNA Catalysis in Splicing and Translation
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs |
| doi_str_mv | 10.1002/wrna.1386 |
| format | Article |
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This article is categorized under:
RNA-Based Catalysis > RNA Catalysis in Splicing and Translation
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs</description><identifier>ISSN: 1757-7004</identifier><identifier>EISSN: 1757-7012</identifier><identifier>DOI: 10.1002/wrna.1386</identifier><identifier>PMID: 27612318</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Animals ; Catalysis ; Cell proliferation ; Cell survival ; Deoxyribonucleic acid ; DNA ; Gene expression ; Gene Expression Regulation ; Humans ; Localization ; MicroRNAs ; miRNA ; Riboswitches ; RNA - genetics ; RNA Splicing - genetics ; RNA-mediated interference ; Splicing ; Stress, Physiological ; Transcription ; Transcription, Genetic ; Translation</subject><ispartof>Wiley interdisciplinary reviews. RNA, 2017-03, Vol.8 (2), p.np-n/a</ispartof><rights>Published 2016. This article is a U.S. Government work and is in the public domain in the USA.</rights><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5706-ef5d8b16ac7d011bf4489720995b8108e749571b99f32466317100226ff10e843</citedby><cites>FETCH-LOGICAL-c5706-ef5d8b16ac7d011bf4489720995b8108e749571b99f32466317100226ff10e843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fwrna.1386$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fwrna.1386$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27612318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panda, Amaresh C.</creatorcontrib><creatorcontrib>Grammatikakis, Ioannis</creatorcontrib><creatorcontrib>Munk, Rachel</creatorcontrib><creatorcontrib>Gorospe, Myriam</creatorcontrib><creatorcontrib>Abdelmohsen, Kotb</creatorcontrib><title>Emerging roles and context of circular RNAs</title><title>Wiley interdisciplinary reviews. RNA</title><addtitle>Wiley Interdiscip Rev RNA</addtitle><description>Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have recently emerged as regulators of gene expression. They have been shown to suppress microRNAs, thereby increasing the translation and stability of the targets of such microRNAs. In this review, we discuss the emerging functions of circRNAs, including RNA transcription, splicing, turnover, and translation. We also discuss other possible facets of circRNAs that can influence their function depending on the cell context, such as circRNA abundance, subcellular localization, interacting partners (RNA, DNA, and proteins), dynamic changes in interactions following stimulation, and potential circRNA translation. The ensuing changes in gene expression patterns elicited by circRNAs are proposed to drive key cellular processes, such as cell proliferation, differentiation, and survival, that govern health and disease. WIREs RNA 2017, 8:e1386. doi: 10.1002/wrna.1386
This article is categorized under:
RNA-Based Catalysis > RNA Catalysis in Splicing and Translation
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs</description><subject>Animals</subject><subject>Catalysis</subject><subject>Cell proliferation</subject><subject>Cell survival</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Localization</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Riboswitches</subject><subject>RNA - genetics</subject><subject>RNA Splicing - genetics</subject><subject>RNA-mediated interference</subject><subject>Splicing</subject><subject>Stress, Physiological</subject><subject>Transcription</subject><subject>Transcription, Genetic</subject><subject>Translation</subject><issn>1757-7004</issn><issn>1757-7012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtLAzEYRYMoWrQL_4AMuFGkmi_vbIRSfIEoiOIyZKaZOjKdaNLx8e_NWC0qKGaTQA4n-e5FaBPwPmBMDp5DY_eBKrGEeiC5HEgMZHlxxmwN9WO8x2kxTCTAKlojUgChoHpo72jqwqRqJlnwtYuZbcZZ4ZuZe5llvsyKKhRtbUN2dTGMG2iltHV0_Y99Hd0cH12PTgfnlydno-H5oOASi4Er-VjlIGwhxxggLxlTWhKsNc8VYOUk01xCrnVJCROCguwGIaIsATvF6Do6nHsf2nzqxoVrZsHW5iFUUxtejbeV-X7TVHdm4p8Mp8AFVUmw8yEI_rF1cWamVSxcXdvG-TYaUJIoUILSf6A8_Z0yTRK6_QO9920Kv06U1kRxRQD_SSmhFAemu2d351QRfIzBlYvpAJsuDdPVarpaE7v1NY4F-VliAg7mwHNVu9ffTeY2tfiufAOi2agj</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Panda, Amaresh C.</creator><creator>Grammatikakis, Ioannis</creator><creator>Munk, Rachel</creator><creator>Gorospe, Myriam</creator><creator>Abdelmohsen, Kotb</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201703</creationdate><title>Emerging roles and context of circular RNAs</title><author>Panda, Amaresh C. ; Grammatikakis, Ioannis ; Munk, Rachel ; Gorospe, Myriam ; Abdelmohsen, Kotb</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5706-ef5d8b16ac7d011bf4489720995b8108e749571b99f32466317100226ff10e843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Catalysis</topic><topic>Cell proliferation</topic><topic>Cell survival</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Localization</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Riboswitches</topic><topic>RNA - genetics</topic><topic>RNA Splicing - genetics</topic><topic>RNA-mediated interference</topic><topic>Splicing</topic><topic>Stress, Physiological</topic><topic>Transcription</topic><topic>Transcription, Genetic</topic><topic>Translation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panda, Amaresh C.</creatorcontrib><creatorcontrib>Grammatikakis, Ioannis</creatorcontrib><creatorcontrib>Munk, Rachel</creatorcontrib><creatorcontrib>Gorospe, Myriam</creatorcontrib><creatorcontrib>Abdelmohsen, Kotb</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Wiley interdisciplinary reviews. RNA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panda, Amaresh C.</au><au>Grammatikakis, Ioannis</au><au>Munk, Rachel</au><au>Gorospe, Myriam</au><au>Abdelmohsen, Kotb</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging roles and context of circular RNAs</atitle><jtitle>Wiley interdisciplinary reviews. RNA</jtitle><addtitle>Wiley Interdiscip Rev RNA</addtitle><date>2017-03</date><risdate>2017</risdate><volume>8</volume><issue>2</issue><spage>np</spage><epage>n/a</epage><pages>np-n/a</pages><issn>1757-7004</issn><eissn>1757-7012</eissn><abstract>Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have recently emerged as regulators of gene expression. They have been shown to suppress microRNAs, thereby increasing the translation and stability of the targets of such microRNAs. In this review, we discuss the emerging functions of circRNAs, including RNA transcription, splicing, turnover, and translation. We also discuss other possible facets of circRNAs that can influence their function depending on the cell context, such as circRNA abundance, subcellular localization, interacting partners (RNA, DNA, and proteins), dynamic changes in interactions following stimulation, and potential circRNA translation. The ensuing changes in gene expression patterns elicited by circRNAs are proposed to drive key cellular processes, such as cell proliferation, differentiation, and survival, that govern health and disease. WIREs RNA 2017, 8:e1386. doi: 10.1002/wrna.1386
This article is categorized under:
RNA-Based Catalysis > RNA Catalysis in Splicing and Translation
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>27612318</pmid><doi>10.1002/wrna.1386</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Catalysis Cell proliferation Cell survival Deoxyribonucleic acid DNA Gene expression Gene Expression Regulation Humans Localization MicroRNAs miRNA Riboswitches RNA - genetics RNA Splicing - genetics RNA-mediated interference Splicing Stress, Physiological Transcription Transcription, Genetic Translation |
| title | Emerging roles and context of circular RNAs |
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