CD28/B7 Deficiency Attenuates Systolic Overload-Induced Congestive Heart Failure, Myocardial and Pulmonary Inflammation, and Activated T Cell Accumulation in the Heart and Lungs

The inflammatory response regulates congestive heart failure (CHF) development. T cell activation plays an important role in tissue inflammation. We postulate that CD28 or B7 deficiency inhibits T cell activation and attenuates CHF development by reducing systemic, cardiac, and pulmonary inflammatio...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2016-09, Vol.68 (3), p.688-696
Hauptverfasser:	Wang, Huan, Kwak, Dongmin, Fassett, John, Hou, Lei, Xu, Xin, Burbach, Brandon J, Thenappan, Thenappan, Xu, Yawei, Ge, Jun-bo, Shimizu, Yoji, Bache, Robert J, Chen, Yingjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept - pharmacology Analysis of Variance Animals B7 Antigens - immunology B7 Antigens - metabolism CD28 Antigens - immunology CD28 Antigens - metabolism Cytokines - drug effects Cytokines - metabolism Disease Models, Animal Heart Failure - immunology Heart Failure - physiopathology Male Mice Mice, Inbred C57BL Mice, Knockout Pneumonia - immunology Pneumonia - physiopathology Random Allocation Statistics, Nonparametric Systole - physiology T-Lymphocytes - drug effects T-Lymphocytes - metabolism
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