Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution

Our current knowledge about the mechanisms of miRNA silencing is restricted to few lineages such as vertebrates, arthropods, nematodes and land plants. miRNA-mediated silencing in bilaterian animals is dependent on the proteins of the GW182 family. Here, we dissect the function of GW182 protein in t...

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Veröffentlicht in:	Nucleic acids research 2017-01, Vol.45 (2), p.938-950
Hauptverfasser:	Mauri, Marta, Kirchner, Marieluise, Aharoni, Reuven, Ciolli Mattioli, Camilla, van den Bruck, David, Gutkovitch, Nadya, Modepalli, Vengamanaidu, Selbach, Matthias, Moran, Yehu, Chekulaeva, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Evolution, Molecular Gene Expression Gene Silencing Humans MicroRNAs - genetics Nucleic Acid Conformation Nucleotide Motifs Protein Binding RNA RNA Interference RNA Stability RNA, Messenger - genetics
Online-Zugang:	Volltext
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