Bacterial Proteasomes: Mechanistic and Functional Insights

Bacterial Proteasomes: Mechanistic and Functional Insights

Regulated proteolysis is essential for the normal physiology of all organisms. While all eukaryotes and archaea use proteasomes for protein degradation, only certain orders of bacteria have proteasomes, whose functions are likely as diverse as the species that use them. In this review, we discuss th...

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Veröffentlicht in:Microbiology and molecular biology reviews 2017-03, Vol.81 (1)
Hauptverfasser: Becker, Samuel H, Darwin, K Heran
Format: Artikel
Sprache:eng
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Adenosine Triphosphate - metabolism
Archaea - metabolism
Bacteria - metabolism
Bacterial Proteins - metabolism
Proteasome Endopeptidase Complex - metabolism
Proteolysis
Review
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Darwin, K Heran
description Regulated proteolysis is essential for the normal physiology of all organisms. While all eukaryotes and archaea use proteasomes for protein degradation, only certain orders of bacteria have proteasomes, whose functions are likely as diverse as the species that use them. In this review, we discuss the most recent developments in the understanding of how proteins are targeted to proteasomes for degradation, including ATP-dependent and -independent mechanisms, and the roles of proteasome-dependent degradation in protein quality control and the regulation of cellular physiology. Furthermore, we explore newly established functions of proteasome system accessory factors that function independently of proteolysis.
doi_str_mv 10.1128/mmbr.00036-16
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source American Society for Microbiology; MEDLINE; PubMed Central
subjects Adenosine Triphosphate - metabolism
Archaea - metabolism
Bacteria - metabolism
Bacterial Proteins - metabolism
Proteasome Endopeptidase Complex - metabolism
Proteolysis
Review
title Bacterial Proteasomes: Mechanistic and Functional Insights
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