MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression

AIM To explore the mechanism by which micro RNA-155(miR-155) regulates the pathogenesis of experimental colitis.METHODS A luciferase assay was performed to confirm the binding of miR-155 to the SHIP-1 3’-UTR. MiR-155 mimics, negative controls and SHIP-1 expression/knockdown vectors were established...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2017-02, Vol.23 (6), p.976-985
Hauptverfasser:	Lu, Zhan-Jun, Wu, Jian-Jiong, Jiang, Wei-Liang, Xiao, Jun-Hua, Tao, Kai-Zhong, Ma, Lei, Zheng, Ping, Wan, Rong, Wang, Xing-Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Antagomirs - administration & dosage Antagomirs - therapeutic use Basic Study Blotting, Western Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - metabolism Cytokines - metabolism Dextran Sulfate - toxicity Disease Models, Animal Down-Regulation Female Immunohistochemistry Mice Mice, Inbred BALB C MicroRNAs - metabolism Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - genetics Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - metabolism Primary Cell Culture Proto-Oncogene Proteins c-akt - metabolism RAW 264.7 Cells RNA Interference RNA, Small Interfering Signal Transduction
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