Drug penetration and metabolism in 3-dimensional cell cultures treated in a 3D printed fluidic device: Assessment of irinotecan via MALDI imaging mass spectrometry

Realistic in vitro models are critical in the drug development process. In this study, a novel in vitro platform is employed to assess drug penetration and metabolism. This platform, which utilizes a 3D printed fluidic device, allows for dynamic dosing of three dimensional cell cultures, also known...

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Veröffentlicht in:	Proteomics (Weinheim) 2016-06, Vol.16 (11-12), p.1814-1821
Hauptverfasser:	LaBonia, Gabriel J., Lockwood, Sarah Y., Heller, Andrew A., Spence, Dana M., Hummon, Amanda B.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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