Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise

Recently, we demonstrated that the hypothalamic S1PR1/STAT3 axis plays a critical role in the control of food consumption and energy expenditure in rodents. Here, we found that reduction of hypothalamic S1PR1 expression occurs in an age-dependent manner, and was associated with defective thermogenic...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2016-12, Vol.9 (1), p.142-155
Hauptverfasser:	Silva, Vagner Ramon Rodrigues, Katashima, Carlos Kiyoshi, Bueno Silva, Carla G, Lenhare, Luciene, Micheletti, Thayana Oliveira, Camargo, Rafael Ludemann, Ghezzi, Ana Carolina, Camargo, Juliana Alves, Assis, Alexandre Moura, Tobar, Natalia, Morari, Joseane, Razolli, Daniela S, Moura, Leandro Pereira, Pauli, José Rodrigo, Cintra, Dennys Esper, Velloso, Lício Augusto, Saad, Mario J A, Ropelle, Eduardo Rochete
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Adipose Tissue, Brown - diagnostic imaging Aging - physiology Animals Energy Metabolism - physiology Homeostasis - physiology Hypothalamus - metabolism Interleukin-6 - blood Lysophospholipids - metabolism Male Mice Oxygen Consumption - physiology Physical Conditioning, Animal - physiology Rats Rats, Wistar Receptors, Lysosphingolipid - metabolism Research Paper Signal Transduction - physiology Sphingosine - analogs & derivatives Sphingosine - metabolism Uncoupling Protein 1 - metabolism
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