Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Abrogates NF-κB Activation in DNA Sensing Signal Pathway

The DNA sensing pathway triggers innate immune responses against DNA virus infection, and NF-κB signaling plays a critical role in establishing innate immunity. We report here that the herpes simplex virus 1 (HSV-1) ubiquitin-specific protease (UL36USP), which is a deubiquitinase (DUB), antagonizes...

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Veröffentlicht in:	Journal of virology 2017-03, Vol.91 (5)
Hauptverfasser:	Ye, Ruijie, Su, Chenhe, Xu, Haiyan, Zheng, Chunfu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cercopithecus aethiops HEK293 Cells Herpesvirus 1, Human - physiology Humans Interferon-beta - physiology NF-kappa B - metabolism Proteolysis Signal Transduction Ubiquitination Vero Cells Viral Proteins - physiology Virus-Cell Interactions
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