Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells
Acetylthevetin B （ATB）, a cardiac glycoside from the seed of Thevetia peruviana （Pers） K Schum （yellow oleander）, exhibits not only antitumor activity but also potential cardiac toxicity. In the present study, we attempted to enhance its antitumor action and decrease its adverse effects via chitosan...
Gespeichert in:
| Veröffentlicht in: | Acta pharmacologica Sinica 2017-02, Vol.38 (2), p.290-300 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 300 |
|---|---|
| container_issue | 2 |
| container_start_page | 290 |
| container_title | Acta pharmacologica Sinica |
| container_volume | 38 |
| creator | Zhu, Jing-jing Zhang, Xin-xin Miao, Yun-qiu He, Shu-fang Tian, Dan-mei Yao, Xin-sheng Tang, Jin-shan Gan, Yong |
| description | Acetylthevetin B （ATB）, a cardiac glycoside from the seed of Thevetia peruviana （Pers） K Schum （yellow oleander）, exhibits not only antitumor activity but also potential cardiac toxicity. In the present study, we attempted to enhance its antitumor action and decrease its adverse effects via chitosan-Pluronic P123 （CP） micelle encapsulation. Two ATB-
loaded CP micelles （ATB-CP1, ATS-CP2） were prepared using an emulsion/solvent evaporation technique. They were spherical in shape with a particle size of 40-50 rim, showed a neutral zeta potential, and had acceptable encapsulation efficiency （〉90%）. Compared to the free ATB （IC50=2.94 μmol/L）, ATB-loaded CP micelles exerted much stronger cytotoxicity against human lung cancer A549 cells with lower IC50 values （0.76 and 1.44 μmol/L for ATB-CP1 and ATB-CP2, respectively）. After administration of a single dose in mice, the accumulation of ATB-ioaded CP1 micelles in the tumor and lungs, respectively, was 15.31-fold and 9.49-fold as high as that of free ATB. A549 xenograft tumor mice treated with ATB- loaded CP1 micelles for 21 d showed the smallest tumor volume （one-fourth of that in the control group） and the highest inhibition rate （85.6%） among all the treatment groups. After 21-d treatment, no significant pathological changes were observed in hearts and other main tissues. In summary, AT8 may serve as a promising antitumor chemotherapeutic agent for lung cancer, and its antitumor efficacy was significantly improved by CP micelles, with lower adverse effects. |
| doi_str_mv | 10.1038/aps.2016.113 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5309751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>671376201</cqvip_id><sourcerecordid>1868332658</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-88afbd86a04432c3eefae1adc6723eef8ebd24a833f3660baaa040586d46d53f3</originalsourceid><addsrcrecordid>eNptkl2L1DAUhoso7rp657UEvfFiOiZNm2ZuFnT9hAVv9DqcSU87WdpkNmkH-jf8xZ4y47CKEMjXc943hzdZ9lLwteBSv4N9WhdcqLUQ8lF2KeqyyuuiKh_TWtUiL7mWF9mzlO44l4UUm6fZRVFvRK1rcZn9-oi9O2CcWWgZWBznftzhAUfn2YcVA09jdOM0hMgsxMaBZV0_25Bcgys2Jec7tg_9PGB0lg3OYt9jYi3x6HfgLTaMFCPscRqJwLZ1FuzMoAPn08j6iRTsApIDFafn2ZMW-oQvTvNV9vPzpx83X_Pb71--3by_zW0l-JhrDe220Qp4WcrCSsQWUEBjVV0sG43bpihBS9lKpfgWgEheadWUqqno8Cq7Purup-2AjUU_RujNProB4mwCOPP3jXc704WDqSTf1JUggbcngRjuJ0yjGVxaWgCPYUpGaEXuhao0oW_-Qe_CFD21t1BVURC5CK6OlI0hpYjt-TGCmyVsQ2GbJWxDYRP-6mEDZ_hPugTkRyDRle8wPnD9v-Drk_8u-O6eSs6a9JNkrYiUvwGxNcQH</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1865226831</pqid></control><display><type>article</type><title>Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhu, Jing-jing ; Zhang, Xin-xin ; Miao, Yun-qiu ; He, Shu-fang ; Tian, Dan-mei ; Yao, Xin-sheng ; Tang, Jin-shan ; Gan, Yong</creator><creatorcontrib>Zhu, Jing-jing ; Zhang, Xin-xin ; Miao, Yun-qiu ; He, Shu-fang ; Tian, Dan-mei ; Yao, Xin-sheng ; Tang, Jin-shan ; Gan, Yong</creatorcontrib><description>Acetylthevetin B （ATB）, a cardiac glycoside from the seed of Thevetia peruviana （Pers） K Schum （yellow oleander）, exhibits not only antitumor activity but also potential cardiac toxicity. In the present study, we attempted to enhance its antitumor action and decrease its adverse effects via chitosan-Pluronic P123 （CP） micelle encapsulation. Two ATB-
loaded CP micelles （ATB-CP1, ATS-CP2） were prepared using an emulsion/solvent evaporation technique. They were spherical in shape with a particle size of 40-50 rim, showed a neutral zeta potential, and had acceptable encapsulation efficiency （〉90%）. Compared to the free ATB （IC50=2.94 μmol/L）, ATB-loaded CP micelles exerted much stronger cytotoxicity against human lung cancer A549 cells with lower IC50 values （0.76 and 1.44 μmol/L for ATB-CP1 and ATB-CP2, respectively）. After administration of a single dose in mice, the accumulation of ATB-ioaded CP1 micelles in the tumor and lungs, respectively, was 15.31-fold and 9.49-fold as high as that of free ATB. A549 xenograft tumor mice treated with ATB- loaded CP1 micelles for 21 d showed the smallest tumor volume （one-fourth of that in the control group） and the highest inhibition rate （85.6%） among all the treatment groups. After 21-d treatment, no significant pathological changes were observed in hearts and other main tissues. In summary, AT8 may serve as a promising antitumor chemotherapeutic agent for lung cancer, and its antitumor efficacy was significantly improved by CP micelles, with lower adverse effects.</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1038/aps.2016.113</identifier><identifier>PMID: 27917871</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biomedicine ; Cardiac Glycosides - administration & dosage ; Cardiac Glycosides - pharmacology ; Cardiac Glycosides - therapeutic use ; Cell Line, Tumor ; Chitosan - chemistry ; Drug Carriers - chemistry ; Humans ; Immunology ; Internal Medicine ; Lung cancer ; Medical Microbiology ; Mice ; Micelles ; Nerium oleander ; Original ; original-article ; Particle Size ; Pharmacology/Toxicology ; Poloxalene - chemistry ; Thevetia peruviana ; Vaccine ; Xenograft Model Antitumor Assays ; 交货 ; 强心苷 ; 抗癌 ; 抗肿瘤作用 ; 抗肿瘤活性 ; 疗效 ; 聚合物胶束 ; 肺癌细胞</subject><ispartof>Acta pharmacologica Sinica, 2017-02, Vol.38 (2), p.290-300</ispartof><rights>CPS and SIMM 2017</rights><rights>Copyright Nature Publishing Group Feb 2017</rights><rights>Copyright © 2017 CPS and SIMM 2017 CPS and SIMM</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-88afbd86a04432c3eefae1adc6723eef8ebd24a833f3660baaa040586d46d53f3</citedby><cites>FETCH-LOGICAL-c510t-88afbd86a04432c3eefae1adc6723eef8ebd24a833f3660baaa040586d46d53f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95561A/95561A.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309751/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309751/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27917871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Jing-jing</creatorcontrib><creatorcontrib>Zhang, Xin-xin</creatorcontrib><creatorcontrib>Miao, Yun-qiu</creatorcontrib><creatorcontrib>He, Shu-fang</creatorcontrib><creatorcontrib>Tian, Dan-mei</creatorcontrib><creatorcontrib>Yao, Xin-sheng</creatorcontrib><creatorcontrib>Tang, Jin-shan</creatorcontrib><creatorcontrib>Gan, Yong</creatorcontrib><title>Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><addtitle>Acta Pharmacologica Sinica</addtitle><description>Acetylthevetin B （ATB）, a cardiac glycoside from the seed of Thevetia peruviana （Pers） K Schum （yellow oleander）, exhibits not only antitumor activity but also potential cardiac toxicity. In the present study, we attempted to enhance its antitumor action and decrease its adverse effects via chitosan-Pluronic P123 （CP） micelle encapsulation. Two ATB-
loaded CP micelles （ATB-CP1, ATS-CP2） were prepared using an emulsion/solvent evaporation technique. They were spherical in shape with a particle size of 40-50 rim, showed a neutral zeta potential, and had acceptable encapsulation efficiency （〉90%）. Compared to the free ATB （IC50=2.94 μmol/L）, ATB-loaded CP micelles exerted much stronger cytotoxicity against human lung cancer A549 cells with lower IC50 values （0.76 and 1.44 μmol/L for ATB-CP1 and ATB-CP2, respectively）. After administration of a single dose in mice, the accumulation of ATB-ioaded CP1 micelles in the tumor and lungs, respectively, was 15.31-fold and 9.49-fold as high as that of free ATB. A549 xenograft tumor mice treated with ATB- loaded CP1 micelles for 21 d showed the smallest tumor volume （one-fourth of that in the control group） and the highest inhibition rate （85.6%） among all the treatment groups. After 21-d treatment, no significant pathological changes were observed in hearts and other main tissues. In summary, AT8 may serve as a promising antitumor chemotherapeutic agent for lung cancer, and its antitumor efficacy was significantly improved by CP micelles, with lower adverse effects.</description><subject>Animals</subject><subject>Biomedicine</subject><subject>Cardiac Glycosides - administration & dosage</subject><subject>Cardiac Glycosides - pharmacology</subject><subject>Cardiac Glycosides - therapeutic use</subject><subject>Cell Line, Tumor</subject><subject>Chitosan - chemistry</subject><subject>Drug Carriers - chemistry</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Lung cancer</subject><subject>Medical Microbiology</subject><subject>Mice</subject><subject>Micelles</subject><subject>Nerium oleander</subject><subject>Original</subject><subject>original-article</subject><subject>Particle Size</subject><subject>Pharmacology/Toxicology</subject><subject>Poloxalene - chemistry</subject><subject>Thevetia peruviana</subject><subject>Vaccine</subject><subject>Xenograft Model Antitumor Assays</subject><subject>交货</subject><subject>强心苷</subject><subject>抗癌</subject><subject>抗肿瘤作用</subject><subject>抗肿瘤活性</subject><subject>疗效</subject><subject>聚合物胶束</subject><subject>肺癌细胞</subject><issn>1671-4083</issn><issn>1745-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkl2L1DAUhoso7rp657UEvfFiOiZNm2ZuFnT9hAVv9DqcSU87WdpkNmkH-jf8xZ4y47CKEMjXc943hzdZ9lLwteBSv4N9WhdcqLUQ8lF2KeqyyuuiKh_TWtUiL7mWF9mzlO44l4UUm6fZRVFvRK1rcZn9-oi9O2CcWWgZWBznftzhAUfn2YcVA09jdOM0hMgsxMaBZV0_25Bcgys2Jec7tg_9PGB0lg3OYt9jYi3x6HfgLTaMFCPscRqJwLZ1FuzMoAPn08j6iRTsApIDFafn2ZMW-oQvTvNV9vPzpx83X_Pb71--3by_zW0l-JhrDe220Qp4WcrCSsQWUEBjVV0sG43bpihBS9lKpfgWgEheadWUqqno8Cq7Purup-2AjUU_RujNProB4mwCOPP3jXc704WDqSTf1JUggbcngRjuJ0yjGVxaWgCPYUpGaEXuhao0oW_-Qe_CFD21t1BVURC5CK6OlI0hpYjt-TGCmyVsQ2GbJWxDYRP-6mEDZ_hPugTkRyDRle8wPnD9v-Drk_8u-O6eSs6a9JNkrYiUvwGxNcQH</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Zhu, Jing-jing</creator><creator>Zhang, Xin-xin</creator><creator>Miao, Yun-qiu</creator><creator>He, Shu-fang</creator><creator>Tian, Dan-mei</creator><creator>Yao, Xin-sheng</creator><creator>Tang, Jin-shan</creator><creator>Gan, Yong</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20170201</creationdate><title>Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells</title><author>Zhu, Jing-jing ; Zhang, Xin-xin ; Miao, Yun-qiu ; He, Shu-fang ; Tian, Dan-mei ; Yao, Xin-sheng ; Tang, Jin-shan ; Gan, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-88afbd86a04432c3eefae1adc6723eef8ebd24a833f3660baaa040586d46d53f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biomedicine</topic><topic>Cardiac Glycosides - administration & dosage</topic><topic>Cardiac Glycosides - pharmacology</topic><topic>Cardiac Glycosides - therapeutic use</topic><topic>Cell Line, Tumor</topic><topic>Chitosan - chemistry</topic><topic>Drug Carriers - chemistry</topic><topic>Humans</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Lung cancer</topic><topic>Medical Microbiology</topic><topic>Mice</topic><topic>Micelles</topic><topic>Nerium oleander</topic><topic>Original</topic><topic>original-article</topic><topic>Particle Size</topic><topic>Pharmacology/Toxicology</topic><topic>Poloxalene - chemistry</topic><topic>Thevetia peruviana</topic><topic>Vaccine</topic><topic>Xenograft Model Antitumor Assays</topic><topic>交货</topic><topic>强心苷</topic><topic>抗癌</topic><topic>抗肿瘤作用</topic><topic>抗肿瘤活性</topic><topic>疗效</topic><topic>聚合物胶束</topic><topic>肺癌细胞</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Jing-jing</creatorcontrib><creatorcontrib>Zhang, Xin-xin</creatorcontrib><creatorcontrib>Miao, Yun-qiu</creatorcontrib><creatorcontrib>He, Shu-fang</creatorcontrib><creatorcontrib>Tian, Dan-mei</creatorcontrib><creatorcontrib>Yao, Xin-sheng</creatorcontrib><creatorcontrib>Tang, Jin-shan</creatorcontrib><creatorcontrib>Gan, Yong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Jing-jing</au><au>Zhang, Xin-xin</au><au>Miao, Yun-qiu</au><au>He, Shu-fang</au><au>Tian, Dan-mei</au><au>Yao, Xin-sheng</au><au>Tang, Jin-shan</au><au>Gan, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells</atitle><jtitle>Acta pharmacologica Sinica</jtitle><stitle>Acta Pharmacol Sin</stitle><addtitle>Acta Pharmacologica Sinica</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>38</volume><issue>2</issue><spage>290</spage><epage>300</epage><pages>290-300</pages><issn>1671-4083</issn><eissn>1745-7254</eissn><abstract>Acetylthevetin B （ATB）, a cardiac glycoside from the seed of Thevetia peruviana （Pers） K Schum （yellow oleander）, exhibits not only antitumor activity but also potential cardiac toxicity. In the present study, we attempted to enhance its antitumor action and decrease its adverse effects via chitosan-Pluronic P123 （CP） micelle encapsulation. Two ATB-
loaded CP micelles （ATB-CP1, ATS-CP2） were prepared using an emulsion/solvent evaporation technique. They were spherical in shape with a particle size of 40-50 rim, showed a neutral zeta potential, and had acceptable encapsulation efficiency （〉90%）. Compared to the free ATB （IC50=2.94 μmol/L）, ATB-loaded CP micelles exerted much stronger cytotoxicity against human lung cancer A549 cells with lower IC50 values （0.76 and 1.44 μmol/L for ATB-CP1 and ATB-CP2, respectively）. After administration of a single dose in mice, the accumulation of ATB-ioaded CP1 micelles in the tumor and lungs, respectively, was 15.31-fold and 9.49-fold as high as that of free ATB. A549 xenograft tumor mice treated with ATB- loaded CP1 micelles for 21 d showed the smallest tumor volume （one-fourth of that in the control group） and the highest inhibition rate （85.6%） among all the treatment groups. After 21-d treatment, no significant pathological changes were observed in hearts and other main tissues. In summary, AT8 may serve as a promising antitumor chemotherapeutic agent for lung cancer, and its antitumor efficacy was significantly improved by CP micelles, with lower adverse effects.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27917871</pmid><doi>10.1038/aps.2016.113</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1671-4083 |
| ispartof | Acta pharmacologica Sinica, 2017-02, Vol.38 (2), p.290-300 |
| issn | 1671-4083 1745-7254 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5309751 |
| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biomedicine Cardiac Glycosides - administration & dosage Cardiac Glycosides - pharmacology Cardiac Glycosides - therapeutic use Cell Line, Tumor Chitosan - chemistry Drug Carriers - chemistry Humans Immunology Internal Medicine Lung cancer Medical Microbiology Mice Micelles Nerium oleander Original original-article Particle Size Pharmacology/Toxicology Poloxalene - chemistry Thevetia peruviana Vaccine Xenograft Model Antitumor Assays 交货 强心苷 抗癌 抗肿瘤作用 抗肿瘤活性 疗效 聚合物胶束 肺癌细胞 |
| title | Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T04%3A21%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Delivery%20of%20acetylthevetin%20B,%20an%20antitumor%20cardiac%20glycoside,%20using%20polymeric%20micelles%20for%20enhanced%20therapeutic%20efficacy%20against%20lung%20cancer%20cells&rft.jtitle=Acta%20pharmacologica%20Sinica&rft.au=Zhu,%20Jing-jing&rft.date=2017-02-01&rft.volume=38&rft.issue=2&rft.spage=290&rft.epage=300&rft.pages=290-300&rft.issn=1671-4083&rft.eissn=1745-7254&rft_id=info:doi/10.1038/aps.2016.113&rft_dat=%3Cproquest_pubme%3E1868332658%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1865226831&rft_id=info:pmid/27917871&rft_cqvip_id=671376201&rfr_iscdi=true |