Inhibition of DNA and Histone Methylation by 5-Aza-2'-Deoxycytidine (Decitabine) and 3-Deazaneplanocin-A on Antineoplastic Action and Gene Expression in Myeloid Leukemic Cells

Epigenetic alterations play an important role in the development of acute myeloid leukemia (AML) by silencing of genes that suppress leukemogenesis and differentiation. One of the key epigenetic changes in AML is gene silencing by DNA methylation. The importance of this alteration is illustrated by...

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Veröffentlicht in:	Frontiers in oncology 2017-02, Vol.7, p.19-19
Hauptverfasser:	Momparler, Richard L, Côté, Sylvie, Momparler, Louise F, Idaghdour, Youssef
Format:	Artikel
Sprache:	eng
Schlagworte:	Oncology
Online-Zugang:	Volltext
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