Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma

In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor...

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Veröffentlicht in:	Oncotarget 2016-09, Vol.7 (38), p.61485-61499
Hauptverfasser:	Marín-Rubio, José L, de Arriba, María C, Cobos-Fernández, María A, González-Sánchez, Laura, Ors, Inmaculada, Sastre, Isabel, Fernández-Piqueras, José, Villa-Morales, María
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Casein Kinase Ialpha - metabolism Cell Proliferation Cytoplasm - metabolism DNA, Complementary - genetics DNA, Complementary - isolation & purification Down-Regulation Dual-Specificity Phosphatases - metabolism Fas-Associated Death Domain Protein - genetics Fas-Associated Death Domain Protein - metabolism Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins - metabolism Jurkat Cells Kaplan-Meier Estimate Leukemia, Experimental - genetics Leukemia, Experimental - mortality Leukemia, Experimental - pathology Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase Phosphatases - metabolism Phosphorylation Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Prognosis Protein-Serine-Threonine Kinases - metabolism Research Paper Risk Assessment - methods Sequence Analysis, DNA Serine - metabolism Thymocytes - metabolism Thymocytes - pathology Up-Regulation
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