The histone methyltransferase G9a as a therapeutic target to override gemcitabine resistance in pancreatic cancer

Gemcitabine (GEM) resistance is a critical issue for pancreatic cancer treatment. The involvement of epigenetic modification in GEM resistance is still unclear. We established a GEM-resistant subline PANC-1-R from the parental PANC-1 pancreatic cancer cells and found the elevation of various chromat...

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Veröffentlicht in:	Oncotarget 2016-09, Vol.7 (38), p.61136-61151
Hauptverfasser:	Pan, Mei-Ren, Hsu, Ming-Chuan, Luo, Chi-Wen, Chen, Li-Tzong, Shan, Yan-Shen, Hung, Wen-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antimetabolites, Antineoplastic - pharmacology Cell Line, Tumor Cell Movement Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Drug Resistance, Neoplasm Extracellular Matrix - metabolism Female Gene Expression Profiling Gene Expression Regulation, Neoplastic HEK293 Cells Histocompatibility Antigens - metabolism Histone Demethylases - metabolism Histone-Lysine N-Methyltransferase - metabolism Humans Interleukin-8 - metabolism Male Mice Middle Aged Neoplasm Invasiveness Neoplasm Metastasis Neoplastic Stem Cells - metabolism Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Stellate Cells - metabolism Receptors, Interleukin-8A - metabolism Research Paper RNA, Small Interfering - metabolism
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