Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome
Objective To find the prevalence of thyroid autoimmunity in PCOS women of reproductive age group. Methods Study design: Observational study was done at ESIMC and PGIMSR K.K. Nagar March 2013–Feb 2014. Ninety cases of women with PCOS based on Rotterdam’s criteria and an equal number of age-matched co...
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| Veröffentlicht in: | Journal of obstetrics and gynaecology of India 2017-02, Vol.67 (1), p.61-65 |
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| container_title | Journal of obstetrics and gynaecology of India |
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| creator | Menon, Maya Ramachandran, Vijayalakshmi |
| description | Objective
To find the prevalence of thyroid autoimmunity in PCOS women of reproductive age group.
Methods
Study design: Observational study was done at ESIMC and PGIMSR K.K. Nagar March 2013–Feb 2014. Ninety cases of women with PCOS based on Rotterdam’s criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Thyroid profile, antithyroid peroxidase titre, serum progesterone, testosterone and fasting blood sugar were estimated using standardised techniques.
Results
Menstrual irregularity (oligomenorrhoea and amenorrhoea) was the most common abnormality found in patients with PCOS compared with non-PCOS (
p
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| doi_str_mv | 10.1007/s13224-016-0914-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5306098</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1872874462</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-e597253473d094d756fc84628fac05ec34dbacb2636a215de2b2f34b45f66cf63</originalsourceid><addsrcrecordid>eNp9kUtP3DAUha2qqAO0P4ANyrKbgH39SjZICJWHhMRIUHVpObYDHmXswc5Q8u_xMIDaDStbPt89ProHoQOCjwjG8jgTCsBqTESNW8Lq6Qvaxa3ktWCUfX29k7oFDDO0l_MCYy4xsG9oBg0waCXeRVenYfTjw5Sit9Xcpfjsrc6u2jx30XqXKx-qP3HpQvW3gNU8DpOZ8uhNdfOk01TdTsGmon9HO70esvvxdu6j3-e_7s4u6-ubi6uz0-vaMAZj7XgrgVMmqcUts5KL3jRMQNNrg7kzlNlOmw4EFRoItw466CnrGO-FML2g--hk67tad0tnjQtj0oNaJb8scVTUXv2vBP-g7uOT4hQL3DbF4OebQYqPa5dHtfTZuGHQwcV1VqSR0EhWMhWUbFGTYs7J9R_fEKw2FahtBapUoDYVqKnMHP6b72PifecFgC2QixTuXVKLuE6h7OwT1xfMWJPM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1872874462</pqid></control><display><type>article</type><title>Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome</title><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Menon, Maya ; Ramachandran, Vijayalakshmi</creator><creatorcontrib>Menon, Maya ; Ramachandran, Vijayalakshmi</creatorcontrib><description>Objective
To find the prevalence of thyroid autoimmunity in PCOS women of reproductive age group.
Methods
Study design: Observational study was done at ESIMC and PGIMSR K.K. Nagar March 2013–Feb 2014. Ninety cases of women with PCOS based on Rotterdam’s criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Thyroid profile, antithyroid peroxidase titre, serum progesterone, testosterone and fasting blood sugar were estimated using standardised techniques.
Results
Menstrual irregularity (oligomenorrhoea and amenorrhoea) was the most common abnormality found in patients with PCOS compared with non-PCOS (
p
< 0.0001). Hyperandrogenism was the second most common manifestation present in PCOS of our study group. Hirsutism was the striking hyperandrogenic feature that was present in study group. PCOS patients had higher BMI compared to controls (
p
< 0.0001). The prevalence of thyroid dysfunction was not significantly different in both the groups (
p
< 0.80). Anti-TPO titre was higher in PCOS patients (25.8 ± 2.9 IU/ml) compared to the controls (14.5 ± 2.3 IU/ml) (
p
< 0.009).
Conclusion
The present study shows that PCOS was associated with increased anti-TPO titres, thus emphasising the importance of screening all PCOS patients for anti-TPO along with routine thyroid profile.</description><identifier>ISSN: 0971-9202</identifier><identifier>EISSN: 0975-6434</identifier><identifier>DOI: 10.1007/s13224-016-0914-y</identifier><identifier>PMID: 28242970</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Gynecology ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Original ; Original Article</subject><ispartof>Journal of obstetrics and gynaecology of India, 2017-02, Vol.67 (1), p.61-65</ispartof><rights>Federation of Obstetric & Gynecological Societies of India 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-e597253473d094d756fc84628fac05ec34dbacb2636a215de2b2f34b45f66cf63</citedby><cites>FETCH-LOGICAL-c442t-e597253473d094d756fc84628fac05ec34dbacb2636a215de2b2f34b45f66cf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306098/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306098/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28242970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Menon, Maya</creatorcontrib><creatorcontrib>Ramachandran, Vijayalakshmi</creatorcontrib><title>Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome</title><title>Journal of obstetrics and gynaecology of India</title><addtitle>J Obstet Gynecol India</addtitle><addtitle>J Obstet Gynaecol India</addtitle><description>Objective
To find the prevalence of thyroid autoimmunity in PCOS women of reproductive age group.
Methods
Study design: Observational study was done at ESIMC and PGIMSR K.K. Nagar March 2013–Feb 2014. Ninety cases of women with PCOS based on Rotterdam’s criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Thyroid profile, antithyroid peroxidase titre, serum progesterone, testosterone and fasting blood sugar were estimated using standardised techniques.
Results
Menstrual irregularity (oligomenorrhoea and amenorrhoea) was the most common abnormality found in patients with PCOS compared with non-PCOS (
p
< 0.0001). Hyperandrogenism was the second most common manifestation present in PCOS of our study group. Hirsutism was the striking hyperandrogenic feature that was present in study group. PCOS patients had higher BMI compared to controls (
p
< 0.0001). The prevalence of thyroid dysfunction was not significantly different in both the groups (
p
< 0.80). Anti-TPO titre was higher in PCOS patients (25.8 ± 2.9 IU/ml) compared to the controls (14.5 ± 2.3 IU/ml) (
p
< 0.009).
Conclusion
The present study shows that PCOS was associated with increased anti-TPO titres, thus emphasising the importance of screening all PCOS patients for anti-TPO along with routine thyroid profile.</description><subject>Gynecology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Original</subject><subject>Original Article</subject><issn>0971-9202</issn><issn>0975-6434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kUtP3DAUha2qqAO0P4ANyrKbgH39SjZICJWHhMRIUHVpObYDHmXswc5Q8u_xMIDaDStbPt89ProHoQOCjwjG8jgTCsBqTESNW8Lq6Qvaxa3ktWCUfX29k7oFDDO0l_MCYy4xsG9oBg0waCXeRVenYfTjw5Sit9Xcpfjsrc6u2jx30XqXKx-qP3HpQvW3gNU8DpOZ8uhNdfOk01TdTsGmon9HO70esvvxdu6j3-e_7s4u6-ubi6uz0-vaMAZj7XgrgVMmqcUts5KL3jRMQNNrg7kzlNlOmw4EFRoItw466CnrGO-FML2g--hk67tad0tnjQtj0oNaJb8scVTUXv2vBP-g7uOT4hQL3DbF4OebQYqPa5dHtfTZuGHQwcV1VqSR0EhWMhWUbFGTYs7J9R_fEKw2FahtBapUoDYVqKnMHP6b72PifecFgC2QixTuXVKLuE6h7OwT1xfMWJPM</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Menon, Maya</creator><creator>Ramachandran, Vijayalakshmi</creator><general>Springer India</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170201</creationdate><title>Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome</title><author>Menon, Maya ; Ramachandran, Vijayalakshmi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-e597253473d094d756fc84628fac05ec34dbacb2636a215de2b2f34b45f66cf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Gynecology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Original</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Menon, Maya</creatorcontrib><creatorcontrib>Ramachandran, Vijayalakshmi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of obstetrics and gynaecology of India</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Menon, Maya</au><au>Ramachandran, Vijayalakshmi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome</atitle><jtitle>Journal of obstetrics and gynaecology of India</jtitle><stitle>J Obstet Gynecol India</stitle><addtitle>J Obstet Gynaecol India</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>67</volume><issue>1</issue><spage>61</spage><epage>65</epage><pages>61-65</pages><issn>0971-9202</issn><eissn>0975-6434</eissn><abstract>Objective
To find the prevalence of thyroid autoimmunity in PCOS women of reproductive age group.
Methods
Study design: Observational study was done at ESIMC and PGIMSR K.K. Nagar March 2013–Feb 2014. Ninety cases of women with PCOS based on Rotterdam’s criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Thyroid profile, antithyroid peroxidase titre, serum progesterone, testosterone and fasting blood sugar were estimated using standardised techniques.
Results
Menstrual irregularity (oligomenorrhoea and amenorrhoea) was the most common abnormality found in patients with PCOS compared with non-PCOS (
p
< 0.0001). Hyperandrogenism was the second most common manifestation present in PCOS of our study group. Hirsutism was the striking hyperandrogenic feature that was present in study group. PCOS patients had higher BMI compared to controls (
p
< 0.0001). The prevalence of thyroid dysfunction was not significantly different in both the groups (
p
< 0.80). Anti-TPO titre was higher in PCOS patients (25.8 ± 2.9 IU/ml) compared to the controls (14.5 ± 2.3 IU/ml) (
p
< 0.009).
Conclusion
The present study shows that PCOS was associated with increased anti-TPO titres, thus emphasising the importance of screening all PCOS patients for anti-TPO along with routine thyroid profile.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>28242970</pmid><doi>10.1007/s13224-016-0914-y</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Gynecology Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Original Original Article |
| title | Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome |
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