CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

Ubiquitous expression of mutant Cu/Zn-superoxide dismutase (SOD1) selectively affects motor neurons in the central nervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis (ALS). The CNS-specific impact of ubiquitous mutant SOD1 expression is recapitulated in...

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Veröffentlicht in:	Scientific reports 2017-02, Vol.7 (1), p.42292-42292, Article 42292
Hauptverfasser:	Hilton, James B., Mercer, Stephen W., Lim, Nastasia K. H., Faux, Noel G., Buncic, Gojko, Beckman, Joseph S., Roberts, Blaine R., Donnelly, Paul S., White, Anthony R., Crouch, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 631/378/1689/1285 631/45/173 631/45/321 64 64/60 82 82/29 Amyotrophic lateral sclerosis Animal models Central nervous system Copper Genotype & phenotype Humanities and Social Sciences Liver Motor neurons Motor task performance multidisciplinary Mutants Oral administration Rodents Science Spinal cord Superoxide dismutase Survival Transgenic mice
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