Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain

Drugs able to treat both nociceptive and neuropathic pain effectively without major side effects are lacking. We developed a bifunctional peptide-based hybrid (KGNOP1) that structurally combines a mu-opioid receptor agonist (KGOP1) with antinociceptive activity and a weak nociceptin receptor antagon...

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Veröffentlicht in:	Pain (Amsterdam) 2017-03, Vol.158 (3), p.505-515
Hauptverfasser:	Lagard, Camille, Chevillard, Lucie, Guillemyn, Karel, Risède, Patricia, Laplanche, Jean-Louis, Spetea, Mariana, Ballet, Steven, Mégarbane, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - therapeutic use Animals Disease Models, Animal Dose-Response Relationship, Drug Hyperalgesia - drug therapy Indoles - therapeutic use Life Sciences Ligands Male Narcotic Antagonists - therapeutic use Neuralgia - drug therapy Nociceptin Nociceptive Pain - drug therapy Oligopeptides - chemistry Oligopeptides - therapeutic use Opioid Peptides - antagonists & inhibitors Pain Measurement Peptides - therapeutic use Phenalenes - therapeutic use Plethysmography Rats Rats, Sprague-Dawley Receptors, Opioid Research Paper Respiration - drug effects Time Factors Toxicology Tramadol - therapeutic use
Online-Zugang:	Volltext
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