Stability, structural and functional properties of a monomeric, calcium–loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis

Bordetella pertussis , the causative agent of whooping cough, secretes an adenylate cyclase toxin, CyaA, which invades eukaryotic cells and alters their physiology by cAMP overproduction. Calcium is an essential cofactor of CyaA, as it is the case for most members of the Repeat-in-ToXins (RTX) famil...

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Veröffentlicht in:	Scientific reports 2017-02, Vol.7 (1), p.42065-42065, Article 42065
Hauptverfasser:	Cannella, Sara E., Ntsogo Enguéné, Véronique Yvette, Davi, Marilyne, Malosse, Christian, Sotomayor Pérez, Ana Cristina, Chamot-Rooke, Julia, Vachette, Patrice, Durand, Dominique, Ladant, Daniel, Chenal, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/535/1261 631/45/56 631/57/2283 82/16 82/58 Adenylate cyclase Adenylate Cyclase Toxin - chemistry Adenylate Cyclase Toxin - metabolism Biochemistry, Molecular Biology Bordetella pertussis - enzymology Calcium Calcium - metabolism Coenzymes - metabolism Conformation Cough Cyclic AMP Cytolysins Humanities and Social Sciences Hydrodynamics Life Sciences Mass Spectrometry Mass spectroscopy multidisciplinary Pertussis Protein Transport Scattering, Small Angle Science Structure-function relationships Toxins Translocation Whooping cough
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