Tanapoxvirus lacking a neuregulin-like gene regresses human melanoma tumors in nude mice

Neuregulin (NRG), an epidermal growth factor is known to promote the growth of various cell types, including human melanoma cells through ErbB family of tyrosine kinases receptors. Tanapoxvirus (TPV)-encoded protein TPV-15L, a functional mimic of NRG, also acts through ErbB receptors. Here, we show...

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Veröffentlicht in:	Virus genes 2017-02, Vol.53 (1), p.52-62
Hauptverfasser:	Zhang, Tiantian, Suryawanshi, Yogesh R., Kordish, Dennis H., Woyczesczyk, Helene M., Jeng, David, Essani, Karim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aotus (Cebidae) Apoptosis - genetics Biomedical and Life Sciences Biomedicine Cell Line Cell Proliferation Disease Models, Animal Epidermal growth factor ErbB protein fibroblasts Gene deletion genes Genetic Vectors - genetics Humans kidney cells Kidneys Male Medical Microbiology Melanoma Melanoma - metabolism Melanoma - pathology Melanoma - therapy Mice Mice, Nude Neuregulin Neuregulins - genetics Oncolysis Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Plant Sciences receptors Recombinants remission Sequence Deletion Thymidine Thymidine kinase Tumor Burden Tumors Tyrosine Viral Proteins - genetics Virology Virus Replication viruses Xenograft Model Antitumor Assays Yatapoxvirus - genetics
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