Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly
Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but o...
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| Veröffentlicht in: | Developmental cell 2017-02, Vol.40 (3), p.221-233 |
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| creator | Wood, Will Martin, Paul |
| description | Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response.
Wood and Martin discuss the similarities between mouse and Drosophila macrophages in the contexts of development, phagocytosis, patterning and immune response, and disease states. They discuss the advances allowed by live imaging and fly genetics, and how insights from both insect and mammalian systems can be combined. |
| doi_str_mv | 10.1016/j.devcel.2017.01.001 |
| format | Article |
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Wood and Martin discuss the similarities between mouse and Drosophila macrophages in the contexts of development, phagocytosis, patterning and immune response, and disease states. They discuss the advances allowed by live imaging and fly genetics, and how insights from both insect and mammalian systems can be combined.</description><subject>Animals</subject><subject>apoptosis</subject><subject>Body Patterning</subject><subject>Cell Lineage</subject><subject>development</subject><subject>Disease</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Humans</subject><subject>immunity</subject><subject>inflammation</subject><subject>macrophage</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - pathology</subject><subject>migration</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>wound</subject><issn>1534-5807</issn><issn>1878-1551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUlvHCEQhVEUK97yD6KIYy7dhm5omBwsRU68SN4OzhmxVM8w6qHHQE_kfx9G43i55EQJXr2ivofQF0pqSmh3sqwdbCwMdUOoqAmtCaEf0AGVQlaUc_qx1LxlFZdE7KPDlJZF0FFJPqH9RlJBBesO0P2NtnFcL_Qc8PkUbPZjSNgH_OBTmgDf65whBh_mWAeHf_oEOsF3fAt_8FVIfr7ICfdxXOG8KA7D0zHa6_WQ4PPzeYR-n_96OLusru8urs5-XFeWN7NcNY3hTjPTaUcE7xkY3UoDTLJeEslaI1zDuJEAQhrJnZhRY1mvyxUXXUvaI3S6811PZgXOQshRD2od_UrHJzVqr96_BL9Q83GjeEsI4VuDb88GcXycIGW18qnwHHSAcUqKyq5r5Ey2tEjZTlpQpRShfxlDidqGoZZqF4bahqEIVYV1afv69osvTf_ov-4ABdTGQ1TJeggWnI9gs3Kj__-Ev7fjncs</recordid><startdate>20170206</startdate><enddate>20170206</enddate><creator>Wood, Will</creator><creator>Martin, Paul</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170206</creationdate><title>Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly</title><author>Wood, Will ; Martin, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-22b5da4b6ad075f4eba38be484f80843b7d245b8ee78b85d791bc4fa5b8576303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>apoptosis</topic><topic>Body Patterning</topic><topic>Cell Lineage</topic><topic>development</topic><topic>Disease</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Humans</topic><topic>immunity</topic><topic>inflammation</topic><topic>macrophage</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - pathology</topic><topic>migration</topic><topic>Review</topic><topic>Signal Transduction</topic><topic>wound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, Will</creatorcontrib><creatorcontrib>Martin, Paul</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Developmental cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, Will</au><au>Martin, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly</atitle><jtitle>Developmental cell</jtitle><addtitle>Dev Cell</addtitle><date>2017-02-06</date><risdate>2017</risdate><volume>40</volume><issue>3</issue><spage>221</spage><epage>233</epage><pages>221-233</pages><issn>1534-5807</issn><eissn>1878-1551</eissn><abstract>Macrophages are multifunctional innate immune cells that seed all tissues within the body and play disparate roles throughout development and in adult tissues, both in health and disease. Their complex developmental origins and many of their functions are being deciphered in mammalian tissues, but opportunities for live imaging and the genetic tractability of Drosophila are offering complementary insights into how these fascinating cells integrate a multitude of guidance cues to fulfill their many tasks and migrate to distant sites to either direct developmental patterning or raise an inflammatory response.
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| ispartof | Developmental cell, 2017-02, Vol.40 (3), p.221-233 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals apoptosis Body Patterning Cell Lineage development Disease Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Humans immunity inflammation macrophage Macrophages - metabolism Macrophages - pathology migration Review Signal Transduction wound |
| title | Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly |
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