A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been rep...
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| Veröffentlicht in: | Biomarker research 2017-02, Vol.5 (1), p.7, Article 7 |
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| creator | Mathias, M D Ortiz, M V Magnan, H Ambati, S R Slotkin, E K Chou, A J Walsh, M F Offit, K Moskowitz, C Kentsis, A Wexler, L H |
| description | Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently.
A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of
or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331.
This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen. |
| doi_str_mv | 10.1186/s40364-017-0086-7 |
| format | Article |
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A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of
or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331.
This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.</description><identifier>ISSN: 2050-7771</identifier><identifier>EISSN: 2050-7771</identifier><identifier>DOI: 10.1186/s40364-017-0086-7</identifier><identifier>PMID: 28194276</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Age ; Cancer therapies ; Care and treatment ; Case Report ; Case studies ; Chemotherapy ; Consent ; Diagnosis ; Family medical history ; Genes ; Lymphatic system ; Lymphoma ; Lymphomas ; Morphology ; Mutation ; Pathology ; Patients ; Pneumonia ; Prostate cancer ; Rhabdomyosarcoma ; Studies ; Tumors</subject><ispartof>Biomarker research, 2017-02, Vol.5 (1), p.7, Article 7</ispartof><rights>COPYRIGHT 2017 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-d99bb5f0500ff8018f38d9f7cbc7b30523dbede6d2fde5e3cb24e16412c1de783</citedby><cites>FETCH-LOGICAL-c495t-d99bb5f0500ff8018f38d9f7cbc7b30523dbede6d2fde5e3cb24e16412c1de783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299656/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299656/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28194276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mathias, M D</creatorcontrib><creatorcontrib>Ortiz, M V</creatorcontrib><creatorcontrib>Magnan, H</creatorcontrib><creatorcontrib>Ambati, S R</creatorcontrib><creatorcontrib>Slotkin, E K</creatorcontrib><creatorcontrib>Chou, A J</creatorcontrib><creatorcontrib>Walsh, M F</creatorcontrib><creatorcontrib>Offit, K</creatorcontrib><creatorcontrib>Moskowitz, C</creatorcontrib><creatorcontrib>Kentsis, A</creatorcontrib><creatorcontrib>Wexler, L H</creatorcontrib><title>A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition</title><title>Biomarker research</title><addtitle>Biomark Res</addtitle><description>Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently.
A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of
or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331.
This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.</description><subject>Age</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case studies</subject><subject>Chemotherapy</subject><subject>Consent</subject><subject>Diagnosis</subject><subject>Family medical history</subject><subject>Genes</subject><subject>Lymphatic system</subject><subject>Lymphoma</subject><subject>Lymphomas</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Pathology</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Prostate cancer</subject><subject>Rhabdomyosarcoma</subject><subject>Studies</subject><subject>Tumors</subject><issn>2050-7771</issn><issn>2050-7771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkt1qHCEYhofS0IQkF9CTIvSoB5Oq44x6UtiG_gQChaQ9Fn8-dw0z41Rn0u5V9JbrsmnYheqBos_76qdvVb0m-IoQ0b3PDDcdqzHhNcaiq_mL6oziFtecc_LyYH5aXeb8gEsTghEiX1WnVBDJKO_Oqj8rZHUGlGCKaUbRIxtHu6QE44xgMGkbR92jtNHGxWEbs042Dhrp0SEXvF-KttdpDehjbaHvUb8dps2OCGOBkHZLP6NfYd7EZUbBFdvggzY9lHNHCwlNCVzIU8xhDnG8qE687jNcPo3n1Y_Pn75ff61vv325uV7d1pbJdq6dlMa0vpSIvReYCN8IJz23xnLT4JY2zoCDzlHvoIXGGsqAdIxQSxxw0ZxXH_a-02IGcLbcK-leTSkMOm1V1EEd74xho9bxUbVUyq7tisHbJ4MUfy6QZ_UQl1TeKisieNO1mNIDaq17UGH0sZjZIWSrVkzgDjMpWaGu_kOV7mAI5T_Ah7J-JHh3JCjMDL_ntV5yVjf3d8cs2bM2xZwT-OciCVa7JKl9klRJktolSfGieXP4Os-Kf7lp_gKhk8Zx</recordid><startdate>20170208</startdate><enddate>20170208</enddate><creator>Mathias, M D</creator><creator>Ortiz, M V</creator><creator>Magnan, H</creator><creator>Ambati, S R</creator><creator>Slotkin, E K</creator><creator>Chou, A J</creator><creator>Walsh, M F</creator><creator>Offit, K</creator><creator>Moskowitz, C</creator><creator>Kentsis, A</creator><creator>Wexler, L H</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20170208</creationdate><title>A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition</title><author>Mathias, M D ; Ortiz, M V ; Magnan, H ; Ambati, S R ; Slotkin, E K ; Chou, A J ; Walsh, M F ; Offit, K ; Moskowitz, C ; Kentsis, A ; Wexler, L H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-d99bb5f0500ff8018f38d9f7cbc7b30523dbede6d2fde5e3cb24e16412c1de783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Case Report</topic><topic>Case studies</topic><topic>Chemotherapy</topic><topic>Consent</topic><topic>Diagnosis</topic><topic>Family medical history</topic><topic>Genes</topic><topic>Lymphatic system</topic><topic>Lymphoma</topic><topic>Lymphomas</topic><topic>Morphology</topic><topic>Mutation</topic><topic>Pathology</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Prostate cancer</topic><topic>Rhabdomyosarcoma</topic><topic>Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mathias, M D</creatorcontrib><creatorcontrib>Ortiz, M V</creatorcontrib><creatorcontrib>Magnan, H</creatorcontrib><creatorcontrib>Ambati, S R</creatorcontrib><creatorcontrib>Slotkin, E K</creatorcontrib><creatorcontrib>Chou, A J</creatorcontrib><creatorcontrib>Walsh, M F</creatorcontrib><creatorcontrib>Offit, K</creatorcontrib><creatorcontrib>Moskowitz, C</creatorcontrib><creatorcontrib>Kentsis, A</creatorcontrib><creatorcontrib>Wexler, L H</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomarker research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mathias, M D</au><au>Ortiz, M V</au><au>Magnan, H</au><au>Ambati, S R</au><au>Slotkin, E K</au><au>Chou, A J</au><au>Walsh, M F</au><au>Offit, K</au><au>Moskowitz, C</au><au>Kentsis, A</au><au>Wexler, L H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition</atitle><jtitle>Biomarker research</jtitle><addtitle>Biomark Res</addtitle><date>2017-02-08</date><risdate>2017</risdate><volume>5</volume><issue>1</issue><spage>7</spage><pages>7-</pages><artnum>7</artnum><issn>2050-7771</issn><eissn>2050-7771</eissn><abstract>Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently.
A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of
or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331.
This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28194276</pmid><doi>10.1186/s40364-017-0086-7</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Age Cancer therapies Care and treatment Case Report Case studies Chemotherapy Consent Diagnosis Family medical history Genes Lymphatic system Lymphoma Lymphomas Morphology Mutation Pathology Patients Pneumonia Prostate cancer Rhabdomyosarcoma Studies Tumors |
| title | A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition |
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