HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium

High-density Lipoprotein (HDL) attenuates endothelial cell apoptosis induced by different cell-death stimuli such as oxidation or growth factor deprivation. HDL is the main plasma carrier of the bioactive lipid sphingosine 1-phosphate (S1P), which it is a signaling molecule that promotes cell surviv...

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Veröffentlicht in:	Lipids in health and disease 2017-02, Vol.16 (1), p.36-36, Article 36
Hauptverfasser:	Ruiz, Mario, Okada, Hiromi, Dahlbäck, Björn
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoproteins - genetics Apolipoproteins - metabolism Apolipoproteins - pharmacology Apolipoproteins M Apoptosis - drug effects Cell Survival - drug effects Culture Media - chemistry Endothelium Gene Expression Health aspects High density lipoproteins Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Lipocalins - genetics Lipocalins - metabolism Lipocalins - pharmacology Lipoproteins, HDL - genetics Lipoproteins, HDL - metabolism Lipoproteins, HDL - pharmacology Lysophospholipids - metabolism Lysophospholipids - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - metabolism Serum Albumin - pharmacology Sphingosine Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine - pharmacology
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