Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms

Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gamet...

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Veröffentlicht in:	Translational psychiatry 2017-01, Vol.7 (1), p.e1019-e1019
Hauptverfasser:	Janecka, M, Mill, J, Basson, M A, Goriely, A, Spiers, H, Reichenberg, A, Schalkwyk, L, Fernandes, C
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/23 631/208/2489 631/477/2811 Age Factors Autistic Disorder - epidemiology Autistic Disorder - genetics Behavioral Sciences Biological Psychology Epigenesis, Genetic Humans Medicine Medicine & Public Health Neurodevelopmental disorders Neurodevelopmental Disorders - epidemiology Neurodevelopmental Disorders - genetics Neurosciences Paternal Age Pharmacotherapy Psychiatry Review Risk Factors Schizophrenia - epidemiology Schizophrenia - genetics
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