Time-Dependent Nerve Growth Factor Signaling Changes in the Rat Retina During Optic Nerve Crush-Induced Degeneration of Retinal Ganglion Cells

Nerve growth factor (NGF) is suggested to be neuroprotective after nerve injury; however, retinal ganglion cells (RGC) degenerate following optic-nerve crush (ONC), even in the presence of increased levels of endogenous NGF. To further investigate this apparently paradoxical condition, a time-course...

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Veröffentlicht in:	International journal of molecular sciences 2017-01, Vol.18 (1), p.98-98
Hauptverfasser:	Mesentier-Louro, Louise A, De Nicolò, Sara, Rosso, Pamela, De Vitis, Luigi A, Castoldi, Valerio, Leocani, Letizia, Mendez-Otero, Rosalia, Santiago, Marcelo F, Tirassa, Paola, Rama, Paolo, Lambiase, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation analysis Animals Apoptosis Blotting, Western Crush tests Damage assessment Degeneration Enzyme-linked immunosorbent assay Evoked Potentials, Visual - physiology Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Growth factors Immunofluorescence Intracellular Intracellular signalling Male Microscopy, Fluorescence Nerve Crush Nerve growth factor Nerve Growth Factor - metabolism Nerve Growth Factors - metabolism Nerve Tissue Proteins - metabolism Neuroprotection Optic nerve Optic Nerve Injuries - complications Protein Precursors - metabolism Rats Rats, Long-Evans Receptor, trkA - metabolism Receptors, Nerve Growth Factor - metabolism Retina Retina - metabolism Retina - physiopathology Retinal degeneration Retinal Degeneration - etiology Retinal Degeneration - metabolism Retinal Degeneration - physiopathology Retinal ganglion cells Retinal Ganglion Cells - metabolism Rodents Signal Transduction Staining Time Factors TrkA protein TrkA receptors
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