Osteogenic Differentiation in Healthy and Pathological Conditions
This review focuses on the osteogenic differentiation of mesenchymal stem cells (MSC), bone formation and turn-over in good and ill skeletal fates. The interacting molecular pathways which control bone remodeling in physiological conditions during a lifelong process are described. Then, alterations...
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| Veröffentlicht in: | International journal of molecular sciences 2017-01, Vol.18 (1), p.41-41 |
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| creator | Valenti, Maria Teresa Dalle Carbonare, Luca Mottes, Monica |
| description | This review focuses on the osteogenic differentiation of mesenchymal stem cells (MSC), bone formation and turn-over in good and ill skeletal fates. The interacting molecular pathways which control bone remodeling in physiological conditions during a lifelong process are described. Then, alterations of the molecular pathways regulating osteogenesis are addressed. In the aging process, as well as in glucocorticoid-induced osteoporosis, bone loss is caused not only by an unbalanced bone resorption activity, but also by an impairment of MSCs' commitment towards the osteogenic lineage, in favour of adipogenesis. Mutations affecting the expression of key genes involved in the control of bone development occur in several heritable bone disorders. A few examples are described in order to illustrate the pathological consequences of perturbation in different steps of osteogenic commitment, osteoblast maturation, and matrix mineralization, respectively. The involvement of abnormal MSC differentiation in cancer is then discussed. Finally, a brief overview of clinical applications of MSCs in bone regeneration and repair is presented. |
| doi_str_mv | 10.3390/ijms18010041 |
| format | Article |
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The interacting molecular pathways which control bone remodeling in physiological conditions during a lifelong process are described. Then, alterations of the molecular pathways regulating osteogenesis are addressed. In the aging process, as well as in glucocorticoid-induced osteoporosis, bone loss is caused not only by an unbalanced bone resorption activity, but also by an impairment of MSCs' commitment towards the osteogenic lineage, in favour of adipogenesis. Mutations affecting the expression of key genes involved in the control of bone development occur in several heritable bone disorders. A few examples are described in order to illustrate the pathological consequences of perturbation in different steps of osteogenic commitment, osteoblast maturation, and matrix mineralization, respectively. The involvement of abnormal MSC differentiation in cancer is then discussed. Finally, a brief overview of clinical applications of MSCs in bone regeneration and repair is presented.</description><subject>Animals</subject><subject>Bone diseases</subject><subject>Bone Diseases - metabolism</subject><subject>Bone Diseases - pathology</subject><subject>Bone Diseases - therapy</subject><subject>Bone Regeneration</subject><subject>Bones</subject><subject>Glucocorticoids</subject><subject>Humans</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Molecular biology</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - metabolism</subject><subject>Osteogenesis</subject><subject>Pathology</subject><subject>Review</subject><subject>Stem cells</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1LAzEQxYMotlZvnmXBiwerk2STbC5CqR8VCnrQc8hmkzZlm9TNVvC_d0tVqidPMzA_Hu_NQ-gUwxWlEq79YplwARggx3uoj3NChgBc7O_sPXSU0gKAUMLkIeqRAiiTkvTR6Cm1Ns5s8Ca79c7ZxobW69bHkPmQTayu2_lHpkOVPet2Hus480bX2TiGym-odIwOnK6TPfmaA_R6f_cyngynTw-P49F0aPKctUPpeOEEEIEZ48wSXkJBhcxLkFUlhMt1AaUAKR0YwsGV2JASuK2sxgaXQAfoZqu7WpdLW5nOZ6NrtWr8UjcfKmqvfl-Cn6tZfFeMSMEF7wQuvgSa-La2qVVLn4ytax1sXCeFC15QoLmk_0BZzjEtmOjQ8z_oIq6b0H1iI0gwltAFHaDLLWWamFJj3Y9vDGpTo9qtscPPdrP-wN-90U9yrZgF</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Valenti, Maria Teresa</creator><creator>Dalle Carbonare, Luca</creator><creator>Mottes, Monica</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3263-6671</orcidid><orcidid>https://orcid.org/0000-0003-1166-8033</orcidid><orcidid>https://orcid.org/0000-0002-7390-2246</orcidid></search><sort><creationdate>20170101</creationdate><title>Osteogenic Differentiation in Healthy and Pathological Conditions</title><author>Valenti, Maria Teresa ; 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| subjects | Animals Bone diseases Bone Diseases - metabolism Bone Diseases - pathology Bone Diseases - therapy Bone Regeneration Bones Glucocorticoids Humans Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Molecular biology Osteoblasts - cytology Osteoblasts - metabolism Osteogenesis Pathology Review Stem cells |
| title | Osteogenic Differentiation in Healthy and Pathological Conditions |
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