A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer
Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups’ design in examining the preliminary effectiveness of nAg against MH and conventional dre...
Gespeichert in:
| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-15 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 15 |
|---|---|
| container_issue | 2017 |
| container_start_page | 1 |
| container_title | Evidence-based complementary and alternative medicine |
| container_volume | 2017 |
| creator | Wong, Thomas Kwok-Shing Chung, Joanne W. Y. Kwong, Enid Wai-Yung Tsang, Ka-Kit To, Tony Shing-Shun |
| description | Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups’ design in examining the preliminary effectiveness of nAg against MH and conventional dressing in healing DFU in terms of ulcer healing, ulcer infection, and inflammation. 31 participants (11 in the nAg group, 10 in the MH group, and 10 in the convention group) diagnosed with type 2 diabetes were enrolled. Wound cleaning, debridement, and topical dressing application were performed according to the group allocation in each visit at weeks 1, 2, 3, 4, 6, 8, 10, and 12. The results found that the proportions of complete ulcer healing were 81.8%, 50%, and 40% in the nAg, MH, and conventional groups, respectively. The ulcer size reduction rate was potentially higher in the nAg group (97.45%) than the MH group (86.21%) and the conventional group (75.17%). In bacteriology, nAg showed a greater rate of microorganism reduction although it was not significant. To conclude, nAg alginate was potentially superior to MH and conventional dressing in healing diabetic foot ulcer in terms of ulcer size reduction rate. |
| doi_str_mv | 10.1155/2017/5294890 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5296609</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A556064377</galeid><sourcerecordid>A556064377</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-14d68131280e9c8fbcebe824e826d63621b051417fc63f19915504260ea74fb3</originalsourceid><addsrcrecordid>eNqNkktvEzEUhUcIREthxxpZYoNEQm2Px49NpShtCVJ5iBaJneWZuZO6OHaxZ1KFH8DvxqOEFFixsHwlfz73-vgUxXOC3xBSVccUE3FcUcWkwg-KQyIYmTIq5cN9Lb4eFE9SusGYKiHE4-KASlqqUsnD4ucMfbIu9Oiz8W1Y2R_QTtA8-D4G56BFl_3QblDo0AfjQxM3qTfOWQ_o0ro1xAl6b_zwzaBF8LCZoCwy3l6D723wxqHTCClZv0TWowUYN5an1tTQ2wadh9z4i2sgPi0edcYleLbbj4qr87Or-WJ68fHtu_nsYtowpfopYS2XpCRUYlCN7OoGapCU5cVbXnJKalwRRkTX8LIjSmWDMKMcgxGsq8uj4mQrezvUK2ibPGY0Tt9GuzJxo4Ox-u8Tb6_1Mqx19pdzrLLAq51ADN8HSL1e2dSAc8ZDGJImUtBKlkxWGX35D3oThpg9GSleVZIQwe-ppXGgre9C7tuMonpWVRxzVgqRqcmWamJIKUK3H5lgPaZAjynQuxRk_MWfz9zDv789A6-3wLX1rbmz_ykHmYHO3NOkYrik5S-IBcMZ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1865581176</pqid></control><display><type>article</type><title>A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Wong, Thomas Kwok-Shing ; Chung, Joanne W. Y. ; Kwong, Enid Wai-Yung ; Tsang, Ka-Kit ; To, Tony Shing-Shun</creator><contributor>Ranzato, Elia</contributor><creatorcontrib>Wong, Thomas Kwok-Shing ; Chung, Joanne W. Y. ; Kwong, Enid Wai-Yung ; Tsang, Ka-Kit ; To, Tony Shing-Shun ; Ranzato, Elia</creatorcontrib><description>Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups’ design in examining the preliminary effectiveness of nAg against MH and conventional dressing in healing DFU in terms of ulcer healing, ulcer infection, and inflammation. 31 participants (11 in the nAg group, 10 in the MH group, and 10 in the convention group) diagnosed with type 2 diabetes were enrolled. Wound cleaning, debridement, and topical dressing application were performed according to the group allocation in each visit at weeks 1, 2, 3, 4, 6, 8, 10, and 12. The results found that the proportions of complete ulcer healing were 81.8%, 50%, and 40% in the nAg, MH, and conventional groups, respectively. The ulcer size reduction rate was potentially higher in the nAg group (97.45%) than the MH group (86.21%) and the conventional group (75.17%). In bacteriology, nAg showed a greater rate of microorganism reduction although it was not significant. To conclude, nAg alginate was potentially superior to MH and conventional dressing in healing diabetic foot ulcer in terms of ulcer size reduction rate.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2017/5294890</identifier><identifier>PMID: 28239398</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Bacteria ; Biomarkers ; Cytokines ; Diabetes ; Diabetics ; Evidence-based nursing ; Foot ; Foot diseases ; Health aspects ; Infections ; Leg ulcers ; Nanocrystals ; Studies ; Tumor necrosis factor-TNF ; Ulcers ; Wound healing</subject><ispartof>Evidence-based complementary and alternative medicine, 2017-01, Vol.2017 (2017), p.1-15</ispartof><rights>Copyright © 2017 Ka-Kit Tsang et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Ka-Kit Tsang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Ka-Kit Tsang et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-14d68131280e9c8fbcebe824e826d63621b051417fc63f19915504260ea74fb3</citedby><cites>FETCH-LOGICAL-c499t-14d68131280e9c8fbcebe824e826d63621b051417fc63f19915504260ea74fb3</cites><orcidid>0000-0003-0321-906X ; 0000-0002-4572-3750</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296609/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296609/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28239398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ranzato, Elia</contributor><creatorcontrib>Wong, Thomas Kwok-Shing</creatorcontrib><creatorcontrib>Chung, Joanne W. Y.</creatorcontrib><creatorcontrib>Kwong, Enid Wai-Yung</creatorcontrib><creatorcontrib>Tsang, Ka-Kit</creatorcontrib><creatorcontrib>To, Tony Shing-Shun</creatorcontrib><title>A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups’ design in examining the preliminary effectiveness of nAg against MH and conventional dressing in healing DFU in terms of ulcer healing, ulcer infection, and inflammation. 31 participants (11 in the nAg group, 10 in the MH group, and 10 in the convention group) diagnosed with type 2 diabetes were enrolled. Wound cleaning, debridement, and topical dressing application were performed according to the group allocation in each visit at weeks 1, 2, 3, 4, 6, 8, 10, and 12. The results found that the proportions of complete ulcer healing were 81.8%, 50%, and 40% in the nAg, MH, and conventional groups, respectively. The ulcer size reduction rate was potentially higher in the nAg group (97.45%) than the MH group (86.21%) and the conventional group (75.17%). In bacteriology, nAg showed a greater rate of microorganism reduction although it was not significant. To conclude, nAg alginate was potentially superior to MH and conventional dressing in healing diabetic foot ulcer in terms of ulcer size reduction rate.</description><subject>Bacteria</subject><subject>Biomarkers</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diabetics</subject><subject>Evidence-based nursing</subject><subject>Foot</subject><subject>Foot diseases</subject><subject>Health aspects</subject><subject>Infections</subject><subject>Leg ulcers</subject><subject>Nanocrystals</subject><subject>Studies</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ulcers</subject><subject>Wound healing</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkktvEzEUhUcIREthxxpZYoNEQm2Px49NpShtCVJ5iBaJneWZuZO6OHaxZ1KFH8DvxqOEFFixsHwlfz73-vgUxXOC3xBSVccUE3FcUcWkwg-KQyIYmTIq5cN9Lb4eFE9SusGYKiHE4-KASlqqUsnD4ucMfbIu9Oiz8W1Y2R_QTtA8-D4G56BFl_3QblDo0AfjQxM3qTfOWQ_o0ro1xAl6b_zwzaBF8LCZoCwy3l6D723wxqHTCClZv0TWowUYN5an1tTQ2wadh9z4i2sgPi0edcYleLbbj4qr87Or-WJ68fHtu_nsYtowpfopYS2XpCRUYlCN7OoGapCU5cVbXnJKalwRRkTX8LIjSmWDMKMcgxGsq8uj4mQrezvUK2ibPGY0Tt9GuzJxo4Ox-u8Tb6_1Mqx19pdzrLLAq51ADN8HSL1e2dSAc8ZDGJImUtBKlkxWGX35D3oThpg9GSleVZIQwe-ppXGgre9C7tuMonpWVRxzVgqRqcmWamJIKUK3H5lgPaZAjynQuxRk_MWfz9zDv789A6-3wLX1rbmz_ykHmYHO3NOkYrik5S-IBcMZ</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Wong, Thomas Kwok-Shing</creator><creator>Chung, Joanne W. Y.</creator><creator>Kwong, Enid Wai-Yung</creator><creator>Tsang, Ka-Kit</creator><creator>To, Tony Shing-Shun</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0321-906X</orcidid><orcidid>https://orcid.org/0000-0002-4572-3750</orcidid></search><sort><creationdate>20170101</creationdate><title>A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer</title><author>Wong, Thomas Kwok-Shing ; Chung, Joanne W. Y. ; Kwong, Enid Wai-Yung ; Tsang, Ka-Kit ; To, Tony Shing-Shun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-14d68131280e9c8fbcebe824e826d63621b051417fc63f19915504260ea74fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bacteria</topic><topic>Biomarkers</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Diabetics</topic><topic>Evidence-based nursing</topic><topic>Foot</topic><topic>Foot diseases</topic><topic>Health aspects</topic><topic>Infections</topic><topic>Leg ulcers</topic><topic>Nanocrystals</topic><topic>Studies</topic><topic>Tumor necrosis factor-TNF</topic><topic>Ulcers</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Thomas Kwok-Shing</creatorcontrib><creatorcontrib>Chung, Joanne W. Y.</creatorcontrib><creatorcontrib>Kwong, Enid Wai-Yung</creatorcontrib><creatorcontrib>Tsang, Ka-Kit</creatorcontrib><creatorcontrib>To, Tony Shing-Shun</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Thomas Kwok-Shing</au><au>Chung, Joanne W. Y.</au><au>Kwong, Enid Wai-Yung</au><au>Tsang, Ka-Kit</au><au>To, Tony Shing-Shun</au><au>Ranzato, Elia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>15</epage><pages>1-15</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups’ design in examining the preliminary effectiveness of nAg against MH and conventional dressing in healing DFU in terms of ulcer healing, ulcer infection, and inflammation. 31 participants (11 in the nAg group, 10 in the MH group, and 10 in the convention group) diagnosed with type 2 diabetes were enrolled. Wound cleaning, debridement, and topical dressing application were performed according to the group allocation in each visit at weeks 1, 2, 3, 4, 6, 8, 10, and 12. The results found that the proportions of complete ulcer healing were 81.8%, 50%, and 40% in the nAg, MH, and conventional groups, respectively. The ulcer size reduction rate was potentially higher in the nAg group (97.45%) than the MH group (86.21%) and the conventional group (75.17%). In bacteriology, nAg showed a greater rate of microorganism reduction although it was not significant. To conclude, nAg alginate was potentially superior to MH and conventional dressing in healing diabetic foot ulcer in terms of ulcer size reduction rate.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28239398</pmid><doi>10.1155/2017/5294890</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-0321-906X</orcidid><orcidid>https://orcid.org/0000-0002-4572-3750</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1741-427X |
| ispartof | Evidence-based complementary and alternative medicine, 2017-01, Vol.2017 (2017), p.1-15 |
| issn | 1741-427X 1741-4288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5296609 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Bacteria Biomarkers Cytokines Diabetes Diabetics Evidence-based nursing Foot Foot diseases Health aspects Infections Leg ulcers Nanocrystals Studies Tumor necrosis factor-TNF Ulcers Wound healing |
| title | A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T09%3A27%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Pilot%20Randomized,%20Controlled%20Study%20of%20Nanocrystalline%20Silver,%20Manuka%20Honey,%20and%20Conventional%20Dressing%20in%20Healing%20Diabetic%20Foot%20Ulcer&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Wong,%20Thomas%20Kwok-Shing&rft.date=2017-01-01&rft.volume=2017&rft.issue=2017&rft.spage=1&rft.epage=15&rft.pages=1-15&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2017/5294890&rft_dat=%3Cgale_pubme%3EA556064377%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1865581176&rft_id=info:pmid/28239398&rft_galeid=A556064377&rfr_iscdi=true |