Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade

Cardiac diseases, such as heart failure, remain leading causes of morbidity and mortality worldwide, with myocardial infarction as the most common etiology. HF is characterized by β-adrenergic receptor (βAR) dysregulation that is primarily due to the upregulation of G protein-coupled receptor kinase...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2017-02, Vol.69 (2), p.71-78
Hauptverfasser:	Cannavo, Alessandro, Koch, Walter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-3 Receptor Agonists - administration & dosage Adrenergic beta-3 Receptor Agonists - metabolism Adrenergic beta-3 Receptor Antagonists - administration & dosage Adrenergic beta-3 Receptor Antagonists - metabolism Animals Drug Delivery Systems - methods Drugs in the Pipeline Heart Heart Diseases - drug therapy Heart Diseases - genetics Heart Diseases - metabolism Humans Receptors, Adrenergic, beta-3 - genetics Receptors, Adrenergic, beta-3 - metabolism
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