TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

MDA5 plays a critical role in antiviral innate immunity by functioning as a cytoplasmic double-stranded RNA sensor that can activate type I interferon signaling pathways, but the mechanism for the activation of MDA5 is poorly understood. Here, we show that TRIM65 specifically interacts with MDA5 and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 2017-02, Vol.214 (2), p.459-473
Hauptverfasser:	Lang, Xueting, Tang, Tiantian, Jin, Tengchuan, Ding, Chen, Zhou, Rongbin, Jiang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AMP Animals Cardiovirus Infections - immunology Cyclic GMP Double-stranded RNA Encephalomyocarditis virus Humans Immunity Immunity, Innate Innate immunity Interferon Interferon regulatory factor Interferon regulatory factor 3 Interferon-Induced Helicase, IFIH1 - chemistry Interferon-Induced Helicase, IFIH1 - physiology Lysine Mice Mice, Inbred C57BL Oligomerization Protein Multimerization Retinoic acid Ribonucleic acid RNA Signal Transduction Signaling TLR3 protein Toll-like receptors Tripartite Motif Proteins - physiology Ubiquitin-protein ligase Ubiquitin-Protein Ligases - physiology Ubiquitination Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!