Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing with Large Defect
Poor viability of engrafted bone marrow mesenchymal stem cells (BMSCs) often hinders their application for wound healing, and the strategy of how to take full advantage of their angiogenic capacity within wounds still remains unclear. Negative pressure wound therapy (NPWT) has been demonstrated to b...
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| Veröffentlicht in: | BioMed research international 2017-01, Vol.2017 (2017), p.1-13 |
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| creator | Yu, Aixi Qi, Baiwen Jian, Chao Ma, Zhanjun Zheng, Xun Niu, Yahui Shou, Kangquan Hu, Xiang |
| description | Poor viability of engrafted bone marrow mesenchymal stem cells (BMSCs) often hinders their application for wound healing, and the strategy of how to take full advantage of their angiogenic capacity within wounds still remains unclear. Negative pressure wound therapy (NPWT) has been demonstrated to be effective for enhancing wound healing, especially for the promotion of angiogenesis within wounds. Here we utilized combinatory strategy using the transplantation of BMSCs and NPWT to investigate whether this combinatory therapy could accelerate angiogenesis in wounds. In vitro, after 9-day culture, BMSCs proliferation significantly increased in NPWT group. Furthermore, NPWT induced their differentiation into the angiogenic related cells, which are indispensable for wound angiogenesis. In vivo, rat full-thickness cutaneous wounds treated with BMSCs combined with NPWT exhibited better viability of the cells and enhanced angiogenesis and maturation of functional blood vessels than did local BMSC injection or NPWT alone. Expression of angiogenesis markers (NG2, VEGF, CD31, and α-SMA) was upregulated in wounds treated with combined BMSCs with NPWT. Our data suggest that NPWT may act as an inductive role to enhance BMSCs angiogenic capacity and this combinatorial therapy may serve as a simple but efficient clinical solution for complex wounds with large defects. |
| doi_str_mv | 10.1155/2017/7920265 |
| format | Article |
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Negative pressure wound therapy (NPWT) has been demonstrated to be effective for enhancing wound healing, especially for the promotion of angiogenesis within wounds. Here we utilized combinatory strategy using the transplantation of BMSCs and NPWT to investigate whether this combinatory therapy could accelerate angiogenesis in wounds. In vitro, after 9-day culture, BMSCs proliferation significantly increased in NPWT group. Furthermore, NPWT induced their differentiation into the angiogenic related cells, which are indispensable for wound angiogenesis. In vivo, rat full-thickness cutaneous wounds treated with BMSCs combined with NPWT exhibited better viability of the cells and enhanced angiogenesis and maturation of functional blood vessels than did local BMSC injection or NPWT alone. Expression of angiogenesis markers (NG2, VEGF, CD31, and α-SMA) was upregulated in wounds treated with combined BMSCs with NPWT. Our data suggest that NPWT may act as an inductive role to enhance BMSCs angiogenic capacity and this combinatorial therapy may serve as a simple but efficient clinical solution for complex wounds with large defects.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2017/7920265</identifier><identifier>PMID: 28243602</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Angiogenesis ; Animals ; Biomarkers - metabolism ; Cell Differentiation ; Cell Proliferation ; Cell Shape ; Cell Survival ; Combined Modality Therapy ; Cytokines - metabolism ; Defects ; Health aspects ; Hypoxia ; Laboratory animals ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells - cytology ; Methods ; Morphology ; Negative-Pressure Wound Therapy ; Neovascularization ; Neovascularization, Physiologic ; Rats, Sprague-Dawley ; Smooth muscle ; Stem cells ; Studies ; Vascular endothelial growth factor ; Wound Healing</subject><ispartof>BioMed research international, 2017-01, Vol.2017 (2017), p.1-13</ispartof><rights>Copyright © 2017 Kangquan Shou et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Kangquan Shou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Kangquan Shou et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-47ac1e88d5091cbeba1b885148242e809c90da30b6fb25253984293ee90133643</citedby><cites>FETCH-LOGICAL-c532t-47ac1e88d5091cbeba1b885148242e809c90da30b6fb25253984293ee90133643</cites><orcidid>0000-0002-1529-4561 ; 0000-0002-3751-0894 ; 0000-0001-7759-9902 ; 0000-0002-8360-9959 ; 0000-0002-7671-2587 ; 0000-0003-0202-5837 ; 0000-0002-3624-5558</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294348/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294348/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28243602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gupta, Subhas</contributor><creatorcontrib>Yu, Aixi</creatorcontrib><creatorcontrib>Qi, Baiwen</creatorcontrib><creatorcontrib>Jian, Chao</creatorcontrib><creatorcontrib>Ma, Zhanjun</creatorcontrib><creatorcontrib>Zheng, Xun</creatorcontrib><creatorcontrib>Niu, Yahui</creatorcontrib><creatorcontrib>Shou, Kangquan</creatorcontrib><creatorcontrib>Hu, Xiang</creatorcontrib><title>Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing with Large Defect</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Poor viability of engrafted bone marrow mesenchymal stem cells (BMSCs) often hinders their application for wound healing, and the strategy of how to take full advantage of their angiogenic capacity within wounds still remains unclear. 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Our data suggest that NPWT may act as an inductive role to enhance BMSCs angiogenic capacity and this combinatorial therapy may serve as a simple but efficient clinical solution for complex wounds with large defects.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Biomarkers - metabolism</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Cell Shape</subject><subject>Cell Survival</subject><subject>Combined Modality Therapy</subject><subject>Cytokines - metabolism</subject><subject>Defects</subject><subject>Health aspects</subject><subject>Hypoxia</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Methods</subject><subject>Morphology</subject><subject>Negative-Pressure Wound Therapy</subject><subject>Neovascularization</subject><subject>Neovascularization, Physiologic</subject><subject>Rats, Sprague-Dawley</subject><subject>Smooth muscle</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Vascular endothelial growth factor</subject><subject>Wound Healing</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0k1r2zAYB3AzNtbS9bbzEOwy2LzqxbKlyyBz23WQboVl9Chk-bGtYkup7DTks-zLViFZ9nKqLzL4pz9-_jxJ8prgj4RwfkYxKc4KSTHN-bPkmDKSpTnJyPPDO2NHyek43uH4CJJjmb9MjqigGcsxPU5-XbhOOwMDuAn5Bn32DtJrHYJfp-cQ7APU6BpGcKbbDLpHPyYYUAl9j2autb4FZw0q9VIbO21QtUHfbm4XqPEBaVT6obJOTz7YeHPRQdDLDZo8ugl-8BOgW79yNboC3VvXorWdOjTXoQV0Dg2Y6VXyotH9CKf78yT5eXmxKK_S-fcvX8vZPDWc0SnNCm0ICFFzLImpoNKkEoKTLA5JQWBpJK41w1XeVJRTzqTIqGQAEsd28oydJJ92uctVNUBtYhVB92oZ7KDDRnlt1b9fnO1U6x8UpzJjmYgB7_YBwd-vYJzUYEcTS9IO_GpURBRUiFyS_GmU8ZzzSN_-R-_8KrjYRFQRCLId5qBa3YOyrvHxF802VM04LximhcRRfdgpE_w4BmgO0xGstpuktpuk9psU-Zu_Gzng33sTwfsd6Kyr9do-MQ6igUb_0YSJiNgjVuXYnQ</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Yu, Aixi</creator><creator>Qi, Baiwen</creator><creator>Jian, Chao</creator><creator>Ma, Zhanjun</creator><creator>Zheng, Xun</creator><creator>Niu, Yahui</creator><creator>Shou, Kangquan</creator><creator>Hu, Xiang</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1529-4561</orcidid><orcidid>https://orcid.org/0000-0002-3751-0894</orcidid><orcidid>https://orcid.org/0000-0001-7759-9902</orcidid><orcidid>https://orcid.org/0000-0002-8360-9959</orcidid><orcidid>https://orcid.org/0000-0002-7671-2587</orcidid><orcidid>https://orcid.org/0000-0003-0202-5837</orcidid><orcidid>https://orcid.org/0000-0002-3624-5558</orcidid></search><sort><creationdate>20170101</creationdate><title>Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing with Large Defect</title><author>Yu, Aixi ; Qi, Baiwen ; Jian, Chao ; Ma, Zhanjun ; Zheng, Xun ; Niu, Yahui ; Shou, Kangquan ; Hu, Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-47ac1e88d5091cbeba1b885148242e809c90da30b6fb25253984293ee90133643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Biomarkers - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Aixi</au><au>Qi, Baiwen</au><au>Jian, Chao</au><au>Ma, Zhanjun</au><au>Zheng, Xun</au><au>Niu, Yahui</au><au>Shou, Kangquan</au><au>Hu, Xiang</au><au>Gupta, Subhas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing with Large Defect</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>13</epage><pages>1-13</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Poor viability of engrafted bone marrow mesenchymal stem cells (BMSCs) often hinders their application for wound healing, and the strategy of how to take full advantage of their angiogenic capacity within wounds still remains unclear. Negative pressure wound therapy (NPWT) has been demonstrated to be effective for enhancing wound healing, especially for the promotion of angiogenesis within wounds. Here we utilized combinatory strategy using the transplantation of BMSCs and NPWT to investigate whether this combinatory therapy could accelerate angiogenesis in wounds. In vitro, after 9-day culture, BMSCs proliferation significantly increased in NPWT group. Furthermore, NPWT induced their differentiation into the angiogenic related cells, which are indispensable for wound angiogenesis. In vivo, rat full-thickness cutaneous wounds treated with BMSCs combined with NPWT exhibited better viability of the cells and enhanced angiogenesis and maturation of functional blood vessels than did local BMSC injection or NPWT alone. Expression of angiogenesis markers (NG2, VEGF, CD31, and α-SMA) was upregulated in wounds treated with combined BMSCs with NPWT. Our data suggest that NPWT may act as an inductive role to enhance BMSCs angiogenic capacity and this combinatorial therapy may serve as a simple but efficient clinical solution for complex wounds with large defects.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28243602</pmid><doi>10.1155/2017/7920265</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-1529-4561</orcidid><orcidid>https://orcid.org/0000-0002-3751-0894</orcidid><orcidid>https://orcid.org/0000-0001-7759-9902</orcidid><orcidid>https://orcid.org/0000-0002-8360-9959</orcidid><orcidid>https://orcid.org/0000-0002-7671-2587</orcidid><orcidid>https://orcid.org/0000-0003-0202-5837</orcidid><orcidid>https://orcid.org/0000-0002-3624-5558</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | BioMed research international, 2017-01, Vol.2017 (2017), p.1-13 |
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| source | MEDLINE; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Angiogenesis Animals Biomarkers - metabolism Cell Differentiation Cell Proliferation Cell Shape Cell Survival Combined Modality Therapy Cytokines - metabolism Defects Health aspects Hypoxia Laboratory animals Male Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Methods Morphology Negative-Pressure Wound Therapy Neovascularization Neovascularization, Physiologic Rats, Sprague-Dawley Smooth muscle Stem cells Studies Vascular endothelial growth factor Wound Healing |
| title | Enhancement of Bone-Marrow-Derived Mesenchymal Stem Cell Angiogenic Capacity by NPWT for a Combinatorial Therapy to Promote Wound Healing with Large Defect |
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