Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis
Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infa...
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| description | Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infarction susceptibility. Relevant case-control studies published between January 2000 and December 2015 were searched and retrieved from the electronic databases of Web of Science, PubMed, Embase and the Chinese Biomedical Database. The odds ratio (OR) with its 95% confidence interval (CI) were employed to calculate the strength of association. A total of 55 articles including 12619 cerebral infarction patients and 14436 controls were screened out. Four ILs (IL-1, IL-6, IL-10 and IL-18) contained nine single nucleotide polymorphisms (SNPs; IL-1α -899C/T, IL-1β -511C/T and IL-1β +3953C/T; IL-6 -174G/C and -572C/G; IL-10 -819C/T and -1082A/G; IL-18 -607C/A and -137G/C). Our result showed that IL-1α -899C/T and IL-18 -607C/A (under all the genetic models), and IL-6 -572C/G (under the allelic model, heterogeneity model and dominant model) were associated with increased the risk of cerebral infarction ( |
| doi_str_mv | 10.1042/BSR20160226 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5293575</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859738326</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-e1b83d3915953e9da3257d06a82e79970e34d5dab6707b51487e1d775d0f1e513</originalsourceid><addsrcrecordid>eNqNkc1LHDEYxoNYdLWevEuOgkyb78x4EFaxHyAUtJ5DZvLOGp1J1mS2Zf_7pt1V9NZTDs-PH8-bB6FjSj5RItjny7tbRqgijKkdNKNS80o0XO6iGaFCVLVQfB8d5PxICCmB2EP7TCvd1IrM0GKec-y8nXwMuIXpN0DACwgw-Q4v47AeY1o--DxmHHvswwRpgNWTDxnb4HAHCdpkh5L0NnX_LMnnp3Ns8QiTrWywwzr7_BF96O2Q4Wj7HqL7L9c_r75VNz--fr-a31SdoGKqgLY1d7yhspEcGmc5k9oRZWsGumk0AS6cdLZVmuhWUlFroE5r6UhPQVJ-iC423uWqHcF1EKZSzyyTH21am2i9eZ8E_2AW8ZeRrPyZlkVwuhWk-LyCPJnR5w6GwQaIq2xorepSikv2H6hsNC-0KujZBu1SzDlB_9qIEvN3RfNmxUKfvD3ilX2Zjf8Bs7CZYg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859738326</pqid></control><display><type>article</type><title>Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis</title><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wang, Jiantao ; Fan, Niannian ; Deng, Yili ; Zhu, Jie ; Mei, Jing ; Chen, Yao ; Yang, Heng</creator><creatorcontrib>Wang, Jiantao ; Fan, Niannian ; Deng, Yili ; Zhu, Jie ; Mei, Jing ; Chen, Yao ; Yang, Heng</creatorcontrib><description>Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infarction susceptibility. Relevant case-control studies published between January 2000 and December 2015 were searched and retrieved from the electronic databases of Web of Science, PubMed, Embase and the Chinese Biomedical Database. The odds ratio (OR) with its 95% confidence interval (CI) were employed to calculate the strength of association. A total of 55 articles including 12619 cerebral infarction patients and 14436 controls were screened out. Four ILs (IL-1, IL-6, IL-10 and IL-18) contained nine single nucleotide polymorphisms (SNPs; IL-1α -899C/T, IL-1β -511C/T and IL-1β +3953C/T; IL-6 -174G/C and -572C/G; IL-10 -819C/T and -1082A/G; IL-18 -607C/A and -137G/C). Our result showed that IL-1α -899C/T and IL-18 -607C/A (under all the genetic models), and IL-6 -572C/G (under the allelic model, heterogeneity model and dominant model) were associated with increased the risk of cerebral infarction (
<0.05). Subgroup analysis by ethnicity showed that IL-6 -174G/C polymorphism (under all the five models) and IL-10 -1082A/G polymorphism (under the allelic model and heterologous model) were significantly associated with increased the cerebral infarction risk in Asians. Other genetic polymorphisms were not related with cerebral infarction susceptibility under any genetic models. In conclusion, IL-1α -899C/T, IL-6 -572C/G and IL-18 -607C/A might be risk factors for cerebral infarction development. Further studies with well-designed and large sample size are still required.</description><identifier>ISSN: 0144-8463</identifier><identifier>EISSN: 1573-4935</identifier><identifier>DOI: 10.1042/BSR20160226</identifier><identifier>PMID: 27679860</identifier><language>eng</language><publisher>England: Portland Press Ltd</publisher><subject>Original Paper ; Original Papers</subject><ispartof>Bioscience reports, 2016-12, Vol.36 (6), p.e00404-e00404</ispartof><rights>2016 The Author(s).</rights><rights>2016 The Author(s) 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-e1b83d3915953e9da3257d06a82e79970e34d5dab6707b51487e1d775d0f1e513</citedby><cites>FETCH-LOGICAL-c414t-e1b83d3915953e9da3257d06a82e79970e34d5dab6707b51487e1d775d0f1e513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293575/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293575/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27679860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jiantao</creatorcontrib><creatorcontrib>Fan, Niannian</creatorcontrib><creatorcontrib>Deng, Yili</creatorcontrib><creatorcontrib>Zhu, Jie</creatorcontrib><creatorcontrib>Mei, Jing</creatorcontrib><creatorcontrib>Chen, Yao</creatorcontrib><creatorcontrib>Yang, Heng</creatorcontrib><title>Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis</title><title>Bioscience reports</title><addtitle>Biosci Rep</addtitle><description>Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infarction susceptibility. Relevant case-control studies published between January 2000 and December 2015 were searched and retrieved from the electronic databases of Web of Science, PubMed, Embase and the Chinese Biomedical Database. The odds ratio (OR) with its 95% confidence interval (CI) were employed to calculate the strength of association. A total of 55 articles including 12619 cerebral infarction patients and 14436 controls were screened out. Four ILs (IL-1, IL-6, IL-10 and IL-18) contained nine single nucleotide polymorphisms (SNPs; IL-1α -899C/T, IL-1β -511C/T and IL-1β +3953C/T; IL-6 -174G/C and -572C/G; IL-10 -819C/T and -1082A/G; IL-18 -607C/A and -137G/C). Our result showed that IL-1α -899C/T and IL-18 -607C/A (under all the genetic models), and IL-6 -572C/G (under the allelic model, heterogeneity model and dominant model) were associated with increased the risk of cerebral infarction (
<0.05). Subgroup analysis by ethnicity showed that IL-6 -174G/C polymorphism (under all the five models) and IL-10 -1082A/G polymorphism (under the allelic model and heterologous model) were significantly associated with increased the cerebral infarction risk in Asians. Other genetic polymorphisms were not related with cerebral infarction susceptibility under any genetic models. In conclusion, IL-1α -899C/T, IL-6 -572C/G and IL-18 -607C/A might be risk factors for cerebral infarction development. Further studies with well-designed and large sample size are still required.</description><subject>Original Paper</subject><subject>Original Papers</subject><issn>0144-8463</issn><issn>1573-4935</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkc1LHDEYxoNYdLWevEuOgkyb78x4EFaxHyAUtJ5DZvLOGp1J1mS2Zf_7pt1V9NZTDs-PH8-bB6FjSj5RItjny7tbRqgijKkdNKNS80o0XO6iGaFCVLVQfB8d5PxICCmB2EP7TCvd1IrM0GKec-y8nXwMuIXpN0DACwgw-Q4v47AeY1o--DxmHHvswwRpgNWTDxnb4HAHCdpkh5L0NnX_LMnnp3Ns8QiTrWywwzr7_BF96O2Q4Wj7HqL7L9c_r75VNz--fr-a31SdoGKqgLY1d7yhspEcGmc5k9oRZWsGumk0AS6cdLZVmuhWUlFroE5r6UhPQVJ-iC423uWqHcF1EKZSzyyTH21am2i9eZ8E_2AW8ZeRrPyZlkVwuhWk-LyCPJnR5w6GwQaIq2xorepSikv2H6hsNC-0KujZBu1SzDlB_9qIEvN3RfNmxUKfvD3ilX2Zjf8Bs7CZYg</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Wang, Jiantao</creator><creator>Fan, Niannian</creator><creator>Deng, Yili</creator><creator>Zhu, Jie</creator><creator>Mei, Jing</creator><creator>Chen, Yao</creator><creator>Yang, Heng</creator><general>Portland Press Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20161201</creationdate><title>Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis</title><author>Wang, Jiantao ; Fan, Niannian ; Deng, Yili ; Zhu, Jie ; Mei, Jing ; Chen, Yao ; Yang, Heng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-e1b83d3915953e9da3257d06a82e79970e34d5dab6707b51487e1d775d0f1e513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Original Paper</topic><topic>Original Papers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jiantao</creatorcontrib><creatorcontrib>Fan, Niannian</creatorcontrib><creatorcontrib>Deng, Yili</creatorcontrib><creatorcontrib>Zhu, Jie</creatorcontrib><creatorcontrib>Mei, Jing</creatorcontrib><creatorcontrib>Chen, Yao</creatorcontrib><creatorcontrib>Yang, Heng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioscience reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jiantao</au><au>Fan, Niannian</au><au>Deng, Yili</au><au>Zhu, Jie</au><au>Mei, Jing</au><au>Chen, Yao</au><au>Yang, Heng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis</atitle><jtitle>Bioscience reports</jtitle><addtitle>Biosci Rep</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>36</volume><issue>6</issue><spage>e00404</spage><epage>e00404</epage><pages>e00404-e00404</pages><issn>0144-8463</issn><eissn>1573-4935</eissn><abstract>Interleukins (ILs) are the most typical inflammatory and immunoregulatory cytokines. Evidences have shown that polymorphisms in ILs are associated with cerebral infarction risk. However, the results remain inconclusive. The present study was to evaluate the role of ILs polymorphisms in cerebral infarction susceptibility. Relevant case-control studies published between January 2000 and December 2015 were searched and retrieved from the electronic databases of Web of Science, PubMed, Embase and the Chinese Biomedical Database. The odds ratio (OR) with its 95% confidence interval (CI) were employed to calculate the strength of association. A total of 55 articles including 12619 cerebral infarction patients and 14436 controls were screened out. Four ILs (IL-1, IL-6, IL-10 and IL-18) contained nine single nucleotide polymorphisms (SNPs; IL-1α -899C/T, IL-1β -511C/T and IL-1β +3953C/T; IL-6 -174G/C and -572C/G; IL-10 -819C/T and -1082A/G; IL-18 -607C/A and -137G/C). Our result showed that IL-1α -899C/T and IL-18 -607C/A (under all the genetic models), and IL-6 -572C/G (under the allelic model, heterogeneity model and dominant model) were associated with increased the risk of cerebral infarction (
<0.05). Subgroup analysis by ethnicity showed that IL-6 -174G/C polymorphism (under all the five models) and IL-10 -1082A/G polymorphism (under the allelic model and heterologous model) were significantly associated with increased the cerebral infarction risk in Asians. Other genetic polymorphisms were not related with cerebral infarction susceptibility under any genetic models. In conclusion, IL-1α -899C/T, IL-6 -572C/G and IL-18 -607C/A might be risk factors for cerebral infarction development. Further studies with well-designed and large sample size are still required.</abstract><cop>England</cop><pub>Portland Press Ltd</pub><pmid>27679860</pmid><doi>10.1042/BSR20160226</doi><oa>free_for_read</oa></addata></record> |
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| title | Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis |
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