P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1

OBJECTIVE—Diabetes mellitus causes vascular endothelial dysfunction and alters vascular microRNA expression. We investigated whether endothelial microRNA-34a (miR-34a) leads to diabetic vascular dysfunction by targeting endothelial sirtuin1 (Sirt1) and asked whether the oxidative stress protein p66S...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2016-12, Vol.36 (12), p.2394-2403
Hauptverfasser:	Li, Qiuxia, Kim, Young-Rae, Vikram, Ajit, Kumar, Santosh, Kassan, Modar, Gabani, Mohanad, Lee, Sang Ki, Jacobs, Julia S, Irani, Kaikobad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Aorta - drug effects Aorta - enzymology Aorta - physiopathology Cells, Cultured Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - genetics Diabetic Angiopathies - enzymology Diabetic Angiopathies - etiology Diabetic Angiopathies - genetics Diabetic Angiopathies - physiopathology Dose-Response Relationship, Drug Down-Regulation Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - physiopathology Energy Metabolism Genotype Glucose - metabolism Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - enzymology Humans Mice, Inbred C57BL Mice, Knockout MicroRNAs - genetics MicroRNAs - metabolism Oxidative Stress Palmitic Acid - metabolism Phenotype RNA Interference Signal Transduction Sirtuin 1 - genetics Sirtuin 1 - metabolism Src Homology 2 Domain-Containing, Transforming Protein 1 - deficiency Src Homology 2 Domain-Containing, Transforming Protein 1 - genetics Src Homology 2 Domain-Containing, Transforming Protein 1 - metabolism Transfection Tumor Suppressor Protein p53 - metabolism Vasodilation - drug effects Vasodilator Agents - pharmacology
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