Biosynthesis of the microtubule-destabilizing diterpene pseudolaric acid B from golden larch involves an unusual diterpene synthase

The diversity of small molecules formed via plant diterpene metabolism offers a rich source of known and potentially new biopharmaceuticals. Among these, the microtubule-destabilizing activity of pseudolaric acid B (PAB) holds promise for new anticancer agents. PAB is found, perhaps uniquely, in the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-01, Vol.114 (5), p.974-979
Hauptverfasser:	Mafu, Sibongile, Karunanithi, Prema Sambandaswami, Palazzo, Teresa Ann, Harrod, Bronwyn Lee, Rodriguez, Selina Marakana, Mollhoff, Iris Natalie, O’Brien, Terrence Edward, Tong, Shen, Fiehn, Oliver, Tantillo, Dean J., Bohlmann, Jörg, Zerbe, Philipp
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Biosynthesis Chemical analysis Coniferous trees Larix Metabolism Molecules Mutagenesis Phylogenetics Phylogeny
Online-Zugang:	Volltext
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