Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry

Apolipoprotein E (apoE) plays a critical role in cholesterol transport in both peripheral circulation and brain. Human apoE is a polymorphic 299-residue protein in which the less common E4 isoform differs from the major E3 isoform only by a C112R substitution. ApoE4 interacts with lipoprotein partic...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-01, Vol.114 (5), p.968-973
Hauptverfasser:	Chetty, Palaniappan S., Mayne, Leland, Lund-Katz, Sissel, Englander, S. Walter, Phillips, Michael C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoproteins Biological Sciences Brain Cholesterol Crystallography Mutation Proteins
Online-Zugang:	Volltext
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