Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib

Dietary flavonoids have many health-promoting actions, including anticancer activity via proteasome inhibition. Bor-tezomib is a dipeptide boronate proteasome inhibitor that has activity in the treatment of multiple myeloma but is not effective in chronic lymphocytic leukemia (CLL). Although CLL cel...

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Veröffentlicht in:	Blood 2008-11, Vol.112 (9), p.3835-3846
Hauptverfasser:	Liu, Feng-Ting, Agrawal, Samir G., Movasaghi, Zanyar, Wyatt, Peter B., Rehman, Ihtesham U., Gribben, John G., Newland, Adrian C., Jia, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - antagonists & inhibitors Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Boric Acids - pharmacology Boronic Acids - antagonists & inhibitors Bortezomib Cell Line, Transformed Cell Line, Tumor Cytochromes c - metabolism Diet - adverse effects Flavonoids - adverse effects Free Radical Scavengers - adverse effects Humans In Vitro Techniques Leukemia, Lymphocytic, Chronic, B-Cell - diet therapy Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphoma, B-Cell - diet therapy Lymphoma, B-Cell - drug therapy Lymphoma, B-Cell - pathology Multiple Myeloma - diet therapy Multiple Myeloma - drug therapy Multiple Myeloma - pathology Neoplasia Protease Inhibitors - pharmacology Pyrazines - antagonists & inhibitors Quercetin - adverse effects
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