Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities

Involuntary weight loss, a part of the cachexia syndrome, is a debilitating comorbidity of cancer and currently has no treatment options. Results from a recent clinical trial at our institution showed that biliary tract cancer patients treated with a MEK inhibitor exhibited poor tumor responses but...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer therapeutics 2017-02, Vol.16 (2), p.344-356
Hauptverfasser:	Talbert, Erin E, Yang, Jennifer, Mace, Thomas A, Farren, Matthew R, Farris, Alton B, Young, Gregory S, Elnaggar, Omar, Che, Zheng, Timmers, Cynthia D, Rajasekera, Priyani, Maskarinec, Jennifer M, Bloomston, Mark, Bekaii-Saab, Tanios, Guttridge, Denis C, Lesinski, Gregory B
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Aminopyridines - pharmacology Animals Anticancer properties Antineoplastic Agents - pharmacology Antitumor activity Benzimidazoles - pharmacology Biliary tract Biomarkers Body Weight - drug effects Cachexia Cachexia - drug therapy Cachexia - etiology Cachexia - pathology Cancer Cell Line, Tumor Cell Proliferation - drug effects Colon Colon cancer Combinatorial analysis Disease Models, Animal Humans In vivo methods and tests Inhibition Inhibitors MEK inhibitors Mice Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Morpholines - pharmacology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Musculoskeletal system Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Signaling Skeletal muscle Therapy Tumor cells Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!