Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance

Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by stem-like cancer cells refractory to existing therapies. Understanding the molecular mechanisms that control glioblastoma stem cell (GSC) proliferation and drug resistance may reveal opportunities for therapeutic in...

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Veröffentlicht in:	Cell stem cell 2017-02, Vol.20 (2), p.233-246.e7
Hauptverfasser:	Liau, Brian B., Sievers, Cem, Donohue, Laura K., Gillespie, Shawn M., Flavahan, William A., Miller, Tyler E., Venteicher, Andrew S., Hebert, Christine H., Carey, Christopher D., Rodig, Scott J., Shareef, Sarah J., Najm, Fadi J., van Galen, Peter, Wakimoto, Hiroaki, Cahill, Daniel P., Rich, Jeremy N., Aster, Jon C., Suvà, Mario L., Patel, Anoop P., Bernstein, Bradley E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Base Sequence Biomarkers, Tumor - metabolism Brain - drug effects Brain - growth & development Brain - pathology cancer Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects chromatin Chromatin Assembly and Disassembly - drug effects drug resistance Drug Resistance, Neoplasm - drug effects Enhancer Elements, Genetic - genetics epigenetics glioblastoma Glioblastoma - metabolism Glioblastoma - pathology histone demethylases Histone Demethylases - metabolism Histones - metabolism Humans Jumonji Domain-Containing Histone Demethylases - metabolism KDM6A/B Lysine - metabolism Methylation - drug effects Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Notch Nuclear Proteins - metabolism Protein Binding - drug effects Protein Kinase Inhibitors - pharmacology Protein Kinases - metabolism Receptors, Notch - metabolism Signal Transduction - drug effects stem cell Transcription, Genetic - drug effects
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