Impact of Single or Combined Genomic Alterations of TP53, MYC, and BCL2 on Survival of Patients With Diffuse Large B-Cell Lymphomas: A Retrospective Cohort Study

MYC and BCL2 translocations as well as TP53 deletion/mutation are known risk factors in diffuse large B-cell lymphoma (DLBCL) but their interplay is not well understood.In this retrospective cohort study, we evaluated the combined prognostic impact of TP53 deletion and mutation status, MYC and BCL2...

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Veröffentlicht in:	Medicine (Baltimore) 2015-12, Vol.94 (52), p.e2388-e2388
Hauptverfasser:	Schiefer, Ana-Iris, Kornauth, Christoph, Simonitsch-Klupp, Ingrid, Skrabs, Cathrin, Masel, Eva Katharina, Streubel, Berthold, Vanura, Katrina, Walter, Karin, Migschitz, Brigitta, Stoiber, Dagmar, Sexl, Veronika, Raderer, Markus, Chott, Andreas, da Silva, Maria Gomes, Cabecadas, Jose, Müllauer, Leonhard, Jäger, Ulrich, Porpaczy, Edit
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Female Humans In Situ Hybridization, Fluorescence Kaplan-Meier Estimate Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - mortality Male Middle Aged Observational Study Pilot Projects Polymorphism, Genetic Proportional Hazards Models Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-myc - genetics Retrospective Studies Sequence Deletion Translocation, Genetic Tumor Suppressor Protein p53 - genetics
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