Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors
Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is re...
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| Veröffentlicht in: | Scientific reports 2017-02, Vol.7 (1), p.41875-41875, Article 41875 |
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| creator | Perretta-Tejedor, Nuria Fernández-Mateos, Javier García-Ortiz, Luis Gómez-Marcos, Manuel A. Recio-Rodríguez, José I. Agudo-Conde, Cristina Rodriguez-Sánchez, Emiliano Morales, Ana I. López-Hernández, Francisco J. López-Novoa, José M. González-Sarmiento, Rogelio Martínez-Salgado, Carlos |
| description | Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms with cardiovascular risk factors and target organ damage (heart, vessels and kidney) in 411 subjects. Our results show that being carrier of the T allele in VAV2 rs602990 polymorphism is associated with an increased risk of obesity, reduced levels of ankle-brachial index and diastolic blood pressure and reduced retinal artery caliber. In addition, being carrier of T allele is associated with increased risk of target organ damage in males. On the other hand, being carrier of the T allele in VAV3 rs7528153 polymorphism is associated with a decreased susceptibility of developing a pathologic state composed by the presence of hypertension, diabetes, obesity or cardiovascular damage, and with an increased risk of developing altered basal glycaemia. This is the first report showing an association between VAV2 and VAV3 polymorphisms with cardiovascular risk factors and target organ damage. |
| doi_str_mv | 10.1038/srep41875 |
| format | Article |
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VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms with cardiovascular risk factors and target organ damage (heart, vessels and kidney) in 411 subjects. Our results show that being carrier of the T allele in VAV2 rs602990 polymorphism is associated with an increased risk of obesity, reduced levels of ankle-brachial index and diastolic blood pressure and reduced retinal artery caliber. In addition, being carrier of T allele is associated with increased risk of target organ damage in males. On the other hand, being carrier of the T allele in VAV3 rs7528153 polymorphism is associated with a decreased susceptibility of developing a pathologic state composed by the presence of hypertension, diabetes, obesity or cardiovascular damage, and with an increased risk of developing altered basal glycaemia. This is the first report showing an association between VAV2 and VAV3 polymorphisms with cardiovascular risk factors and target organ damage.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep41875</identifier><identifier>PMID: 28157227</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/77 ; 692/308/575 ; 692/700/459 ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Ankle ; Ankle Brachial Index ; Blood glucose ; Blood Glucose - metabolism ; Blood Pressure ; Body Weight ; Cardiovascular diseases ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - pathology ; Case-Control Studies ; Diabetes ; Diabetes mellitus ; Female ; Guanosine ; Guanosine triphosphatases ; Health risk assessment ; Health risks ; Heterozygote ; Homeostasis ; Humanities and Social Sciences ; Humans ; Hypertension ; Kidneys ; Male ; Middle Aged ; multidisciplinary ; Obesity ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins c-vav - genetics ; Proto-oncogenes ; Retina ; Retinal Artery - pathology ; Risk factors ; Science ; Sex Factors</subject><ispartof>Scientific reports, 2017-02, Vol.7 (1), p.41875-41875, Article 41875</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Feb 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-95ba9e2c4f4e38bb0755d23e2b7963d85b9c1c048ad52100a2d6b1cb4746295c3</citedby><cites>FETCH-LOGICAL-c438t-95ba9e2c4f4e38bb0755d23e2b7963d85b9c1c048ad52100a2d6b1cb4746295c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291103/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291103/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28157227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perretta-Tejedor, Nuria</creatorcontrib><creatorcontrib>Fernández-Mateos, Javier</creatorcontrib><creatorcontrib>García-Ortiz, Luis</creatorcontrib><creatorcontrib>Gómez-Marcos, Manuel A.</creatorcontrib><creatorcontrib>Recio-Rodríguez, José I.</creatorcontrib><creatorcontrib>Agudo-Conde, Cristina</creatorcontrib><creatorcontrib>Rodriguez-Sánchez, Emiliano</creatorcontrib><creatorcontrib>Morales, Ana I.</creatorcontrib><creatorcontrib>López-Hernández, Francisco J.</creatorcontrib><creatorcontrib>López-Novoa, José M.</creatorcontrib><creatorcontrib>González-Sarmiento, Rogelio</creatorcontrib><creatorcontrib>Martínez-Salgado, Carlos</creatorcontrib><title>Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms with cardiovascular risk factors and target organ damage (heart, vessels and kidney) in 411 subjects. Our results show that being carrier of the T allele in VAV2 rs602990 polymorphism is associated with an increased risk of obesity, reduced levels of ankle-brachial index and diastolic blood pressure and reduced retinal artery caliber. In addition, being carrier of T allele is associated with increased risk of target organ damage in males. On the other hand, being carrier of the T allele in VAV3 rs7528153 polymorphism is associated with a decreased susceptibility of developing a pathologic state composed by the presence of hypertension, diabetes, obesity or cardiovascular damage, and with an increased risk of developing altered basal glycaemia. This is the first report showing an association between VAV2 and VAV3 polymorphisms with cardiovascular risk factors and target organ damage.</description><subject>38/77</subject><subject>692/308/575</subject><subject>692/700/459</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Ankle</subject><subject>Ankle Brachial Index</subject><subject>Blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Body Weight</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Female</subject><subject>Guanosine</subject><subject>Guanosine triphosphatases</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heterozygote</subject><subject>Homeostasis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Kidneys</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Obesity</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proto-Oncogene Proteins c-vav - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perretta-Tejedor, Nuria</au><au>Fernández-Mateos, Javier</au><au>García-Ortiz, Luis</au><au>Gómez-Marcos, Manuel A.</au><au>Recio-Rodríguez, José I.</au><au>Agudo-Conde, Cristina</au><au>Rodriguez-Sánchez, Emiliano</au><au>Morales, Ana I.</au><au>López-Hernández, Francisco J.</au><au>López-Novoa, José M.</au><au>González-Sarmiento, Rogelio</au><au>Martínez-Salgado, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-02-03</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>41875</spage><epage>41875</epage><pages>41875-41875</pages><artnum>41875</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms with cardiovascular risk factors and target organ damage (heart, vessels and kidney) in 411 subjects. Our results show that being carrier of the T allele in VAV2 rs602990 polymorphism is associated with an increased risk of obesity, reduced levels of ankle-brachial index and diastolic blood pressure and reduced retinal artery caliber. In addition, being carrier of T allele is associated with increased risk of target organ damage in males. On the other hand, being carrier of the T allele in VAV3 rs7528153 polymorphism is associated with a decreased susceptibility of developing a pathologic state composed by the presence of hypertension, diabetes, obesity or cardiovascular damage, and with an increased risk of developing altered basal glycaemia. This is the first report showing an association between VAV2 and VAV3 polymorphisms with cardiovascular risk factors and target organ damage.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28157227</pmid><doi>10.1038/srep41875</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 38/77 692/308/575 692/700/459 Adult Aged Aged, 80 and over Alleles Ankle Ankle Brachial Index Blood glucose Blood Glucose - metabolism Blood Pressure Body Weight Cardiovascular diseases Cardiovascular Diseases - genetics Cardiovascular Diseases - pathology Case-Control Studies Diabetes Diabetes mellitus Female Guanosine Guanosine triphosphatases Health risk assessment Health risks Heterozygote Homeostasis Humanities and Social Sciences Humans Hypertension Kidneys Male Middle Aged multidisciplinary Obesity Polymorphism, Single Nucleotide Proto-Oncogene Proteins c-vav - genetics Proto-oncogenes Retina Retinal Artery - pathology Risk factors Science Sex Factors |
| title | Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors |
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