Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine

Functional avidity of T cells is a critical determinant for clearing viral infection and eliminating tumor. Understanding how functional avidity is maintained in T cells is imperative for immunotherapy. However, studies systematically characterize T cell with high functional avidity induced in vivo...

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Veröffentlicht in:	Scientific reports 2017-02, Vol.7 (1), p.41558-41558, Article 41558
Hauptverfasser:	Hu, Zhidong, Zhu, Lingyan, Wang, Jing, Wan, Yanmin, Yuan, Songhua, Chen, Jian, Ding, Xiangqing, Qiu, Chenli, Zhang, Xiaoyan, Qiu, Chao, Xu, Jianqing
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/44 631/250/251 631/250/590/1867 64/60 Animals Antigens Avidity CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell cycle Cell interactions Cytokines Cytotoxicity, Immunologic Disease Models, Animal DNA vaccines Epitopes, T-Lymphocyte - immunology Gene Expression Profiling Genetic Vectors - genetics Humanities and Social Sciences Immunization Immunologic Memory Immunotherapy Lymphocytes Lymphocytes T Mice Models, Biological multidisciplinary Myeloid Differentiation Factor 88 - metabolism Phenotyping Science Signal Transduction T-Cell Antigen Receptor Specificity Transcription Transcriptome Vaccination Vaccines Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccinia Vaccinia virus - genetics Viral Vaccines - genetics Viral Vaccines - immunology
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