Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs

[Display omitted] •The synthesis of novel 2′,2′,3′,3′-tetrafluoro nucleoside analogs is described.•Glycosylation reactions are achieved via Mitsunobu coupling.•Energetics of ring conformation are compared to differently substituted ribose.•Evaluation of Tetrafluoronucleosides in vitro against a pane...

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Veröffentlicht in:	Tetrahedron letters 2017-02, Vol.58 (7), p.642-644
Hauptverfasser:	Sari, Ozkan, Bassit, Leda, Gavegnano, Christina, McBrayer, Tamara R., McCormick, Louise, Cox, Bryan, Coats, Steven J., Amblard, Franck, Schinazi, Raymond F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral antiviral properties chemical reactions chemical structure DNA Fluorine Human immunodeficiency virus Mitsunobu Nucleoside nucleosides organic compounds Prodrug RNA viruses viruses
Online-Zugang:	Volltext
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